Harold E. Varmus

Harold Varmus
Born	December 18, 1939 (1939-12-18) Oceanside, New York, U.S.
Fields	Cell biology
Alma mater	Amherst College Harvard University Columbia University
Known for	Retroviral oncogenes
Notable awards	1989 Nobel Prize in Physiology or Medicine

Harold Elliot Varmus (born December 18, 1939) is an American Nobel Prize-winning scientist and the 14th and current Director of the National Cancer Institute, a post he was appointed to by President Barack Obama. He was a co-recipient (along with J. Michael Bishop) of the 1989 Nobel Prize in Physiology or Medicine for discovery of the cellular origin of retroviral oncogenes.

He also serves as one of three co-Chairs of the President's Council of Advisors on Science and Technology.

Biography

Varmus was born to Jewish parents of Eastern European descent in Oceanside, New York. In 1957, he enrolled at Amherst College, intending to follow in his father's footsteps as a medical doctor, but eventually graduating with a B.A. in English literature. He went on to earn a graduate degree in English at Harvard University in 1962 before changing his mind once again and applying to medical schools. He got rejected from Harvard Medical School twice. That same year, he entered the Columbia University College of Physicians and Surgeons and later worked at a missionary hospital in Bareilly, India and the Columbia-Presbyterian Hospital. As an alternative to serving militarily in the Vietnam War, Varmus joined the Public Health Service at the National Institutes of Health in 1968. Working under Ira Pastan, he researched the regulation of bacterial gene expression by cyclic AMP. In 1970, he began post-doctoral studies in Bishop's lab at University of California, San Francisco. There, he and Bishop performed the oncogene research that would win them the Nobel Prize. He became a faculty member at UCSF in 1972 and a professor in 1979. In 1989, Bishop and Varmus were awarded the Nobel Prize. Varmus described the work in his Nobel lecture.

From 1993 to 1999, he served as Director of the National Institutes of Health. As the NIH director, Varmus was credited with nearly doubling the research agency's budget. From 2000 to 2010, he was President of Memorial Sloan-Kettering Cancer Center in New York City. He was also the Chairman of the Geoffrey Beene Cancer Research Center at Memorial Sloan-Kettering Cancer Center. From 2002 to 2005, he served as a trustee of Columbia University.

Varmus while at Sloan-Kettering

On January 12, 2010, Memorial Sloan-Kettering Cancer Center announced that Varmus "has asked the MSKCC Boards of Overseers and Managers to begin a search for his successor." The announcement also stated, "Varmus indicated that he plans to continue in his present position until a successor has been identified, and he will remain the head of his laboratory in the Cancer Biology and Genetics Program at the Sloan-Kettering Institute and an active member of the teaching faculty."

On May 18, 2010, Varmus was nominated to be the director of the National Cancer Institute, and he began his tenure as NCI director on July 12, 2010.

Beginning during his tenure as NIH director, Varmus has been a champion of an open access system for scientific papers, arguing that scientists should have control over the dissemination of their research rather than journal editors. He has advocated a system in which journals make their articles freely available on PubMed Central six months after publication. He is co-founder and chairman of the board of directors of the Public Library of Science, a not-for-profit open access publisher, and he also sits on the board of trustees of BioMed Central, the largest publisher of open-access journals. He currently serves on the advisory boards of the Campaign to Defend the Constitution, an organization dedicated to opposing the religious right, and Scientists and Engineers for America, an organization focused on promoting sound science in American government.

He is also a 2001 recipient of the National Medal of Science, served on the board of the Science Initiative Group and received an honorary degree in 2010 from the University of Massachusetts Medical School.

Private life

Varmus is an avid bicyclist and an Advisory Committee member of Transportation Alternatives the New York City-based advocacy group for pedestrians and cyclists. He is also a runner, rower, and fisherman. He has been married to Constance Casey since 1969 and has two sons, Jacob and Christopher. He and his son Jacob, a trumpet player, have performed a series of concerts entitled "Genes and Jazz" at the Guggenheim and the Smithsonian.

Politics

Varmus endorsed then-United States Senator Barack Obama (D-Illinois) for the 2008 presidential election. He has been selected as one of co-chairs of the Council of Advisors on Science and Technology to serve in the Obama administration.

Books

• Harold Varmus (2009). The Art and Politics of Science. W. W. Norton. ISBN 9780393061284. OCLC 227016094. http://www.wwnorton.com/catalog/winter09/006128.htm. 

See also

• List of Jewish Nobel laureates

External links

• The Harold Varmus Papers - Profiles in Science, National Library of Medicine
• 1989 Prize Lecture in Physiology or Medicine at NobelPrize.org
• Harold Varmus iBioMagazine talk: "How I Became a Scientist"
• President's Council of Advisors on Science and Technology
  • President-elect Obama introduces Dr. Varmus as Co-Chair of PCAST, YouTube
• Board member profile at the Public Library of Science
• Harold Varmus iBioMagazine talk: "Changing the Way We Publish"
• Appearances on C-SPAN
• Harold E. Varmus on Charlie Rose
• Harold E. Varmus at the Internet Movie Database
• Works by or about Harold E. Varmus in libraries (WorldCat catalog)
• Archives:
  • Personal Papers of Harold Varmus I - UCSF Archives & Special Collections
  • Personal Papers of Harold Varmus II - UCSF Archives & Special Collections
  • Personal Papers of Harold Varmus III - UCSF Archives & Special Collections
• Access Excellence Biography
• Memorial Sloan-Kettering Cancer Center Biography
• Audio: Harold Varmus in conversation on the BBC World Service discussion show The Forum
• Review: Michael A. Rogawski. "The Art and Politics of Science (book review)" Perspectives in Biology and Medicine 52.1 (2009): 637-642.

Political offices
Preceded by Bernadine Healy	Director of the National Institutes of Health 1993–1999	Succeeded by Elias Zerhouni