A-349,821
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| Systematic (IUPAC) name | |
| (4'-[3-(2R,5R-dimethylpyrrolidin-1-yl)propoxy]biphenyl-4-yl)morpholin-4-ylmethanone | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| ATC code | ? |
| PubChem | CID 9954017 |
| IUPHAR ligand | 1217 |
| ChemSpider | 8129627  |
| ChEMBL | CHEMBL179702 |
| Chemical data | |
| Formula | C26H34N2O3 |
| Mol. mass | 422.558 |
| SMILES | eMolecules & PubChem |
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A-349,821 is a potent and selective histamine H3 receptor antagonist[1] (or possibly an inverse agonist).[2] It has nootropic effects in animal studies,[3] although there do not appear to be any plans for clinical development at present and it is currently only used in laboratory research.
[edit] See also
[edit] References
- ^ Faghih, R; Dwight, W; Pan, JB; Fox, GB; Krueger, KM; Esbenshade, TA; McVey, JM; Marsh, K et al. (2003). "Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists". Bioorganic & medicinal chemistry letters 13 (7): 1325–8. doi:10.1016/S0960-894X(03)00118-5. PMID 12657274.
- ^ Witte, DG; Yao, BB; Miller, TR; Carr, TL; Cassar, S; Sharma, R; Faghih, R; Surber, BW et al. (2006). "Detection of multiple H3 receptor affinity states utilizing 3HA-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand". British journal of pharmacology 148 (5): 657–70. doi:10.1038/sj.bjp.0706752. PMC 1751875. PMID 16715122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1751875.
- ^ Esbenshade, TA; Fox, GB; Krueger, KM; Baranowski, JL; Miller, TR; Kang, CH; Denny, LI; Witte, DG et al. (2004). "Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist". Biochemical pharmacology 68 (5): 933–45. doi:10.1016/j.bcp.2004.05.048. PMID 15294456.
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