GPR126
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| G protein-coupled receptor 126 | ||||||||
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| Identifiers | ||||||||
| Symbols | GPR126; APG1; DREG; PS1TP2; VIGR | |||||||
| External IDs | OMIM: 612243 MGI: 1916151 HomoloGene: 10724 IUPHAR: GPR126 GeneCards: GPR126 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 57211 | 215798 | ||||||
| Ensembl | ENSG00000112414 | ENSMUSG00000039116 | ||||||
| UniProt | Q86SQ4 | Q6F3F9 | ||||||
| RefSeq (mRNA) | NM_001032394.2 | NM_001002268.3 | ||||||
| RefSeq (protein) | NP_001027566.1 | NP_001002268.1 | ||||||
| Location (UCSC) | Chr 6: 142.62 – 142.77 Mb |
Chr 10: 14.4 – 14.55 Mb |
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| PubMed search | [1] | [2] | ||||||
Probable G-protein coupled receptor 126 is a protein that in humans is encoded by the GPR126 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family [3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4] It is involved in the process of myelination.[5]
[edit] References
- ^ Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
- ^ "Entrez Gene: GPR126 G protein-coupled receptor 126". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57211.
- ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/.
- ^ Monk KR, Oshima K, Jörs S, Heller S, Talbot WS (May 2011). "Gpr126 is essential for peripheral nerve development and myelination in mammals". Development 138 (13): 2673–2680. doi:10.1242/dev.062224. PMC 3109596. PMID 21613327. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3109596/. Lay summary – news.wustl.edu.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kristiansen TZ, Bunkenborg J, Gronborg M, et al. (2005). "A proteomic analysis of human bile". Mol. Cell Proteomics 3 (7): 715–28. doi:10.1074/mcp.M400015-MCP200. PMID 15084671.
- Moriguchi T, Haraguchi K, Ueda N, et al. (2005). "DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites". Genes Cells 9 (6): 549–60. doi:10.1111/j.1356-9597.2004.00743.x. PMID 15189448.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Stehlik C, Kroismayr R, Dorfleutner A, et al. (2004). "VIGR--a novel inducible adhesion family G-protein coupled receptor in endothelial cells". FEBS Lett. 569 (1–3): 149–55. doi:10.1016/j.febslet.2004.05.038. PMID 15225624.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
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