Fosaprepitant
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| Systematic (IUPAC) name | |
| [3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid | |
| Clinical data | |
| AHFS/Drugs.com | Multum Consumer Information |
| MedlinePlus | a604003 |
| Licence data | EMA:Link, US FDA:link |
| Pregnancy cat. | B(US) |
| Legal status | ℞-only (US) |
| Routes | Intravenous |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | >95% (aprepitant) |
| Metabolism | To aprepitant |
| Half-life | 9 to 13 hours (aprepitant) |
| Identifiers | |
| CAS number | 172673-20-0  265121-04-8 (dimeglumine) |
| ATC code | A04AD12 |
| PubChem | CID 219090 |
| DrugBank | DB06717 |
| UNII | 6L8OF9XRDC  |
| KEGG | D06597 |
| ChEMBL | CHEMBL1199324 |
| Chemical data | |
| Formula | C23H22F7N4O6P |
| Mol. mass | 614.406 g/mol |
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Fosaprepitant (Emend for Injection (US), Ivemend (EU)) is an antiemetic drug, administered intravenously. It is a prodrug of aprepitant.
Fosaprepitant was developed by Merck & Co. and was approved by the United States Food and Drug Administration (FDA) on January 25, 2008.[1] and by the European Medicines Agency (EMA) on January 11 of the same year.[2]
[edit] See also
[edit] References
- ^ "Drugs.com, FDA Approves Emend (fosaprepitant dimeglumine) for Injection, Merck's New Intravenous Therapy, for Use in Combination with Other Antiemetics for Prevention of Nausea and Vomiting Caused by Chemotherapy". http://www.drugs.com/newdrugs/fda-approves-emend-fosaprepitant-dimeglumine-merck-s-new-intravenous-therapy-combination-other-833.html. Retrieved 2008-03-15.
- ^ "European Public Assessment Report for Ivemend (from the EMEA website)". http://www.emea.europa.eu/humandocs/Humans/EPAR/ivemend/ivemend.htm. Retrieved 2008-03-15.
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