The Wayback Machine - https://web.archive.org/web/20111128163741/http://en.wikipedia.org/wiki/Ebalzotan

Ebalzotan

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ebalzotan
Systematic (IUPAC) name
(3R)-N-(propan-2-yl)-3-[propan-2-yl(propyl)amino]-3,4-dihydro-2H-chromene-5-carboxamide
Clinical data
Pregnancy cat.  ?
Legal status Uncontrolled
Routes Oral
Identifiers
CAS number 149494-37-1
ATC code None
PubChem CID 9797080
ChemSpider 7972846
UNII WV4B56N49H YesY
Chemical data
Formula C19H30N2O2 
Mol. mass 318.45 g/mol
SMILES eMolecules & PubChem

Ebalzotan (NAE-086) is a selective 5-HT1A receptor agonist.[1][2] It was under development as an antidepressant and anxiolytic agent but produced undesirable side effects in phase I clinical trials and was subsequently discontinued.[1][2]

[edit] See also

[edit] References

  1. ^ a b Tamim Braish; Gadamasetti, Kumar G. (2008). Process chemistry in the pharmaceutical industry, volume 2 challenges in an ever changing climate. Boca Raton: CRC Press. ISBN 0-8493-9051-6. http://books.google.com/books?id=-zG1pnP0x9gC&lpg=PA112&dq=Ebalzotan&pg=PA112#v=onepage&q=&f=false. 
  2. ^ a b Weaver, Donald F.; Nogrady, Thomas; Nogrady, Th (2005). Medicinal chemistry a molecular and biochemical approach. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-510455-2. http://books.google.com/books?id=EkxCWOoYB2wC&lpg=PA255&dq=Ebalzotan&pg=PA255#v=onepage&q=&f=false. 


v · d · eAnxiolytics (N05B)
GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
Retrieved from "http://en.wikipedia.org/w/index.php?title=Ebalzotan&oldid=451552508"
Personal tools
Namespaces
Variants
Actions
Navigation
Interaction
Toolbox
Print/export
Morty Proxy This is a proxified and sanitized view of the page, visit original site.