KLF11

Kruppel-like factor 11
Identifiers
Symbols	KLF11; FKLF; FKLF1; MODY7; TIEG2; Tieg3
External IDs	OMIM: 603301 MGI: 2653368 HomoloGene: 2668 GeneCards: KLF11 Gene
Gene Ontology Molecular function • sequence-specific DNA binding RNA polymerase II transcription factor activity • DNA binding • sequence-specific DNA binding transcription factor activity • zinc ion binding • transcription regulatory region DNA binding • metal ion binding Cellular component • intracellular • nucleus Biological process • regulation of transcription involved in S phase of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of cell proliferation • positive regulation of apoptosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8462	194655
Ensembl	ENSG00000172059	ENSMUSG00000020653
UniProt	O14901	Q8BHJ1
RefSeq (mRNA)	NM_001177716.1	NM_178357.3
RefSeq (protein)	NP_001171187.1	NP_848134.1
Location (UCSC)	Chr 2: 10.18 – 10.19 Mb	Chr 12: 25.34 – 25.35 Mb
PubMed search	[1]	[2]

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.

Interactions

KLF11 has been shown to interact with SIN3A.

See also

• Kruppel-like factors
• Maturity onset diabetes of the young

Further reading

• Asano H, Li XS, Stamatoyannopoulos G (1999). "FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.". Mol. Cell. Biol. 19 (5): 3571–9. PMC 84149. PMID 10207080. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84149. 
• Zhang JS, Moncrieffe MC, Kaczynski J, et al. (2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A.". Mol. Cell. Biol. 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC 87230. PMID 11438660. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87230. 
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis.". Genomics 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452. 
• Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor.". EMBO J. 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC 126002. PMID 12006497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126002. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Ou XM, Chen K, Shih JC (2004). "Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene.". J. Biol. Chem. 279 (20): 21021–8. doi:10.1074/jbc.M312638200. PMID 15024015. 
• Ellenrieder V, Buck A, Harth A, et al. (2004). "KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells.". Gastroenterology 127 (2): 607–20. doi:10.1053/j.gastro.2004.05.018. PMID 15300592. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Cao S, Fernandez-Zapico ME, Jin D, et al. (2005). "KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling.". J. Biol. Chem. 280 (3): 1901–10. doi:10.1074/jbc.M407941200. PMID 15531587. 
• Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, et al. (2005). "Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.". Proc. Natl. Acad. Sci. U.S.A. 102 (13): 4807–12. doi:10.1073/pnas.0409177102. PMC 554843. PMID 15774581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554843. 
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• Buck A, Buchholz M, Wagner M, et al. (2007). "The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer.". Mol. Cancer Res. 4 (11): 861–72. doi:10.1158/1541-7786.MCR-06-0081. PMID 17114344. 
• Florez JC, Saxena R, Winckler W, et al. (2007). "The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people.". Diabetes 55 (12): 3620–4. doi:10.2337/db06-0867. PMID 17130512. 
• Spittau B, Wang Z, Boinska D, Krieglstein K (2007). "Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain.". J. Cell. Biochem. 101 (3): 712–22. doi:10.1002/jcb.21228. PMID 17252542. 
• Niu X, Perakakis N, Laubner K, et al. (2007). "Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.". Diabetologia 50 (7): 1433–41. doi:10.1007/s00125-007-0667-3. PMID 17479246. 

External links

• MeSH KLF11+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.