Avram Hershko

Avram Hershko
Born	31 December 1937(1937-12-31) Karcag, Hungary
Nationality	Israel
Fields	Chemistry
Known for	ubiquitin-mediated protein degradation
Notable awards	Nobel Prize in Chemistry (2004)

Avram Hershko (Hebrew: אברהם הרשקו‎) (born 31 December 1937) is a Hungarian-Israeli biochemist and Nobel laureate in Chemistry.

Biography

Born Herskó Ferenc in Karcag, Hungary, Hershko emigrated to Israel in 1950. Received his M.D. in 1965 and his Ph.D in 1969 from the Hebrew University-Hadassah Medical School, Jerusalem, Israel. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.

Honours and awards

• 1987 – Weizmann Prize for Sciences (Israel)
• 1994 – Israel Prize in biochemistry
• 1999 – Gairdner International Award Canada (with A. Varshavsky)
• 2000 – Albert Lasker Award for Basic Medical Research (with A. Ciechanover and A. Varshavsky).
• 2001 – Louisa Gross Horwitz Prize from Columbia University
• 2001 – Wolf Prize in Medicine (Israel), jointly with Alexander Varshavsky, for 'the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation."
• 2003 – Foreign Associate, National Academy of Sciences, USA
• 2004 – Nobel Prize in Chemistry for his discovery with Aaron Ciechanover and Irwin Rose, of ubiquitin-mediated protein degradation.

In 2005, he was voted the co-31st-greatest Israeli of all time, in a poll by the Israeli news website Ynet to determine whom the general public considered the 200 Greatest Israelis. Hershko's work and reception of the Nobel Prize is cited as a historic milestone in the unique history of the Technion - Israel Institute of Technology.

Publications

• Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, 1783–1786.
• Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206–8214.
• Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619–1623.
• Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
• Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.
• Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hershko, J., Luca, F.C., Ruderman, J.V. and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–198.

Involvement with Biotechnology

Professor Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.

External links

• Nobel Prize lecture
• Website at the Technion
• Avram Hershko iBioMagazine talk: "Lessons from My Life in Science"
• "Hungarian" Nobel Prize winners Crooked Timber
• Avram Hershko Jewish Virtual Library
• Ubiquitin-Mediated Protein Degradation: From the lab to the bedside Dan Hersko
• The Official Site of Louisa Gross Horwitz Prize

See also

• List of Israel Prize recipients
• List of Jewish Nobel laureates