FOXF1

Forkhead box F1
Identifiers
Symbols	FOXF1; ACDMPV; FKHL5; FREAC1; MGC105125
External IDs	OMIM: 601089 MGI: 1347470 HomoloGene: 1114 GeneCards: FOXF1 Gene
Gene Ontology Molecular function • DNA binding • double-stranded DNA binding • sequence-specific enhancer binding RNA polymerase II transcription factor activity • transcription factor binding • DNA bending activity • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • blood vessel development • vasculogenesis • in utero embryonic development • somitogenesis • positive regulation of mesenchymal cell proliferation • endocardial cushion development • cardiac left ventricle morphogenesis • smoothened signaling pathway • determination of left/right symmetry • pattern specification process • midgut development • mesoderm development • heart development • embryo development • tissue development • positive regulation of cell-substrate adhesion • detection of wounding • cell-cell adhesion • extracellular matrix organization • lung development • positive regulation of cell migration • pancreas development • negative regulation of mast cell degranulation • establishment of epithelial cell apical/basal polarity • positive regulation of transcription, DNA-dependent • lung alveolus development • lateral mesodermal cell differentiation • embryonic digestive tract morphogenesis • digestive tract development • embryonic ectodermal digestive tract morphogenesis • embryonic foregut morphogenesis • negative regulation of inflammatory response • regulation of sequence-specific DNA binding transcription factor activity • regulation of smooth muscle cell differentiation • lung vasculature development • trachea development • epithelial tube branching involved in lung morphogenesis • branching involved in open tracheal system development • right lung morphogenesis • lung lobe morphogenesis • venous blood vessel development • epithelial cell differentiation involved in mammary gland alveolus development • cellular response to cytokine stimulus • cellular response to organic cyclic compound • renal system development • ureter development • mesenchyme migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2294	15227
Ensembl	ENSG00000103241	ENSMUSG00000042812
UniProt	Q12946	Q61080
RefSeq (mRNA)	NM_001451	NM_010426.1
RefSeq (protein)	NP_001442	NP_034556.1
Location (UCSC)	Chr 16: 86.54 – 86.55 Mb	Chr 8: 123.61 – 123.61 Mb
PubMed search	[1]	[2]

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.

Further reading

• Murphy DB, Wiese S, Burfeind P, et al. (1994). "Human brain factor 1, a new member of the fork head gene family.". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731. 
• Hellqvist M, Mahlapuu M, Samuelsson L, et al. (1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.". J. Biol. Chem. 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802. 
• Hellqvist M, Mahlapuu M, Blixt A, et al. (1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.". J. Biol. Chem. 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567. 
• Mahlapuu M, Pelto-Huikko M, Aitola M, et al. (1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces.". Dev. Biol. 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Coon DR, Roberts DJ, Loscertales M, Kradin R (2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia.". Exp. Mol. Pathol. 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649. 
• Lomenick JP, Hubert MA, Handwerger S (2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression.". Am. J. Physiol. Endocrinol. Metab. 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323. 

External links

• MeSH FOXF1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.