SPIB

Spi-B transcription factor (Spi-1/PU.1 related)
Identifiers
Symbols	SPIB; SPI-B
External IDs	OMIM: 606802 MGI: 892986 HomoloGene: 79220 GeneCards: SPIB Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus • cytoplasm • microtubule cytoskeleton Biological process • regulation of transcription from RNA polymerase II promoter • macrophage differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6689	272382
Ensembl	ENSG00000142539	ENSMUSG00000008193
UniProt	Q01892	O35906
RefSeq (mRNA)	NM_003121	NM_019866.1
RefSeq (protein)	NP_003112	NP_063919.1
Location (UCSC)	Chr 19: 50.92 – 50.93 Mb	Chr 7: 51.78 – 51.79 Mb
PubMed search	[1]	[2]

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM]

Interactions

SPIB has been shown to interact with MAPK3 and MAPK8.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. PMID 8632909. 
• Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "An alternatively spliced isoform of the Spi-B transcription factor". Biochem. Biophys. Res. Commun. 223 (2): 257–63. doi:10.1006/bbrc.1996.0881. PMID 8670269. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196. 
• Nagy M, Chapuis B, Matthes T (2002). "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells". Br. J. Haematol. 116 (2): 429–35. doi:10.1046/j.1365-2141.2002.03271.x. PMID 11841448. 
• Yamamoto H, Kihara-Negishi F, Yamada T, et al. (2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". Cell Growth Differ. 13 (2): 69–75. PMID 11864910. 
• Schotte R, Rissoan MC, Bendriss-Vermare N, et al. (2003). "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development". Blood 101 (3): 1015–23. doi:10.1182/blood-2002-02-0438. PMID 12393575. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Schotte R, Nagasawa M, Weijer K, et al. (2005). "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development". J. Exp. Med. 200 (11): 1503–9. doi:10.1084/jem.20041231. PMC 2211952. PMID 15583020. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2211952. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Geng CD, Vedeckis WV (2006). "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter". J. Biol. Chem. 280 (52): 43264–71. doi:10.1074/jbc.M508245200. PMID 16263717. 
• Dontje W, Schotte R, Cupedo T, et al. (2006). "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood 107 (6): 2446–52. doi:10.1182/blood-2005-05-2090. PMID 16317090. 

External links

• MeSH SPIB+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.