KLF3

Kruppel-like factor 3 (basic)
	; PDB rendering based on 1p7a.
Available structures
PDB	1p7a, 1u85, 1u86
Identifiers
Symbols	KLF3; BKLF; MGC48279
External IDs	OMIM: 609392 MGI: 1342773 HomoloGene: 7396 GeneCards: KLF3 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • zinc ion binding; • metal ion binding;
Cellular component	• intracellular; • nucleus;
Biological process	• transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • multicellular organismal development;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Krueppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.^[1]^[2]KLF3 is a member of the Krüppel-like factors family of transcription factors. KLF3 primarily represses transcription through the transcriptional corepressor C-terminal binding protein (CtBP). KLF3's PVDLT (amino acids 61-65) domain, present in its N-terminal variable region, is necessary for its interaction with CtBP. The repression mediated through KLF3 is also partially dependent on the sumoylation of its K10 and K197. Within KLF3's C-terminal, which is highly conserved throughout the KLF family, resides three C₂H₂ zinc fingers that preferentially bind the site NRG GNG NGR (where R is a purine).^[3]

[edit] Interactions

KLF3 has been shown to interact with FHL3^[4] and CTBP2.^[4]^[5]

[edit] References

^ Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M (Jun 2008). "Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis". Mol Cell Biol 28 (12): 3967–78. doi:10.1128/MCB.01942-07. PMC 2423134. PMID 18391014. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2423134.
^ "Entrez Gene: KLF3 Kruppel-like factor 3 (basic)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51274.
^ The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF)
^ ^a ^b Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451.
^ Turner, J; Crossley M (Sep. 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. (ENGLAND) 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. ISSN 0261-4189. PMC 1170841. PMID 9724649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170841.

[edit] Further reading

Turner J, Crossley M (2000). "Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors". Int. J. Biochem. Cell Biol. 31 (10): 1169–74. doi:10.1016/S1357-2725(99)00067-9. PMID 10582345.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170841.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wang MJ, Qu XH, Wang LS, et al. (2003). "[cDNA cloning, subcellular localization and tissue expression of a new human Krüppel-like transcription factor: human basic Krüppel-like factor (hBKLF)]". Yi Chuan Xue Bao 30 (1): 1–9. PMID 12812068.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Perdomo J, Verger A, Turner J, Crossley M (2005). "Role for SUMO modification in facilitating transcriptional repression by BKLF". Mol. Cell. Biol. 25 (4): 1549–59. doi:10.1128/MCB.25.4.1549-1559.2005. PMC 548027. PMID 15684403. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=548027.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

[edit] External links

MeSH KLF3 protein, human

This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.

[pmid18391014-0] Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M (Jun 2008). "Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis". Mol Cell Biol 28 (12): 3967–78. doi:10.1128/MCB.01942-07. PMC 2423134. PMID 18391014. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2423134.

[entrez-1] "Entrez Gene: KLF3 Kruppel-like factor 3 (basic)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51274.

[2] The mammalian zinc finger transcription factor Krüppel-like factor 3 (KLF3/BKLF)

[pmid12556451-3] Turner, Jeremy; Nicholas Hannah, Bishop David, Matthews Jacqueline M, Crossley Merlin (Apr. 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". J. Biol. Chem. (United States) 278 (15): 12786–95. doi:10.1074/jbc.M300587200. ISSN 0021-9258. PMID 12556451.

[pmid9724649-4] Turner, J; Crossley M (Sep. 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. (ENGLAND) 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. ISSN 0261-4189. PMC 1170841. PMID 9724649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170841.

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KLF3

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