WAY-317,538

WAY-317,538
Systematic (IUPAC) name
	5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide
Clinical data
Pregnancy cat.	?
Legal status	Legal
Identifiers
ATC code	?
ChEMBL	CHEMBL1084615
Chemical data
Formula	C20H25N3O2
Mol. mass	339.430
SMILES	eMolecules & PubChem
(what is this?) (verify);

From Wikipedia, the free encyclopedia

Jump to: navigation, search

WAY-317,538 (SEN-12333) is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors. It was not the most potent compound in the series, but was selected for further development on the basis of its high selectivity over related receptors, ease of synthesis, and good in vivo properties including high oral bioavailability and good brain penetration.^[1] It has nootropic and neuroprotective effects in animal studies, and is being investigated as a potential treatment for neurodegenerative conditions including Alzheimer's disease and schizophrenia.^[2]

[edit] References

^ Haydar, S.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.; Dunlop, J.; La Rosa, S.; Micco, I. et al. (2009). "SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.". Bioorganic & medicinal chemistry 17 (14): 5247–5258. doi:10.1016/j.bmc.2009.05.040. PMID 19515567. edit
^ Roncarati, R.; Scali, C.; Comery, T.; Grauer, S.; Aschmi, S.; Bothmann, H.; Jow, B.; Kowal, D. et al. (2009). "Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders". The Journal of pharmacology and experimental therapeutics 329 (2): 459–468. doi:10.1124/jpet.108.150094. PMID 19223665. edit

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

[0] Haydar, S.; Ghiron, C.; Bettinetti, L.; Bothmann, H.; Comery, T.; Dunlop, J.; La Rosa, S.; Micco, I. et al. (2009). "SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist.". Bioorganic & medicinal chemistry 17 (14): 5247–5258. doi:10.1016/j.bmc.2009.05.040. PMID 19515567. edit

[1] Roncarati, R.; Scali, C.; Comery, T.; Grauer, S.; Aschmi, S.; Bothmann, H.; Jow, B.; Kowal, D. et al. (2009). "Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders". The Journal of pharmacology and experimental therapeutics 329 (2): 459–468. doi:10.1124/jpet.108.150094. PMID 19223665. edit

[1]

[2]

Oct	NOV	Dec
	29
2010	2011	2012

WAY-317,538

[edit] References

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Interaction

Toolbox

Print/export