Xylometazoline
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| Systematic (IUPAC) name | |
| 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]- 4,5-dihydro-1H-imidazole |
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| Clinical data | |
| Trade names | Otrivin |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Intranasal spray or drops |
| Pharmacokinetic data | |
| Half-life | very short |
| Identifiers | |
| CAS number | 526-36-3  |
| ATC code | R01AA07 S01GA03 |
| PubChem | CID 5709 |
| IUPHAR ligand | 517 |
| DrugBank | DB06694 |
| ChemSpider | 5507 |
| UNII | WPY40FTH8K  |
| KEGG | D08684 |
| ChEMBL | CHEMBL312448 |
| Chemical data | |
| Formula | C16H24N2 |
| Mol. mass | 244.37516 g/mol |
| SMILES | eMolecules & PubChem |
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Xylometazoline (also known as xylomethazoline) is a drug which is used as a topical nasal decongestant.[1] It is applied directly into the nose, either as a spray or as drops.
Xylometazoline is marketed under many brand names (see below), with the typical adult dose being 0.1% w/v xylometazoline, and the dose for children under 12 being 0.05%.[citation needed]
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[edit] Mechanism of action
The drug works by constricting the blood vessels in the nose. The vasoconstriction means that there is less pressure in the capillaries and less water can filter out, thus less discharge is made. (If the colour of the nasal passage is observed, it is visibly paler after dosage.)
Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to alpha-adrenergic receptors in the nasal mucosa.[2] Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems.
Extended usage of xylometazoline can result in decreased effectiveness or a build up of tolerance against the drug.[3] The number of receptors decreases, and when the administration of the drug is ceased, chronic congestion can occur; this is called rhinitis medicamentosa, commonly referred to as rebound congestion. Moreover long-term overdosing can cause degenerative changes in nasal mucous membranes that pose another health problem.
[edit] Brand names
Xylometazoline is sold under a number of brand names worldwide, including: Xylomet(Opsonin,BD)Cirovin, Klarigen (in Denmark), Nasolin, Neo-Rinoleina, Novorin, Olynth, Otrinoz, Otriven, Otrivin, Otrivine, Otrix, Sinutab Nasal Spray, Snup akut, Sudafed, Xylo-COMOD, Xylovit, Zolynd (in Serbia), Xynosine (in Pakistan), Xymelin and Zymelin.
[edit] Chemistry
- H. Albrecht, U.S. Patent 2,868,802 (1959).
- H. Albrecht, DE 1049387 (1957).
[edit] See also
[edit] References
- ^ Eccles, R.; Eriksson, M.; Garreffa, S.; Chen, S. (2008). "The nasal decongestant effect of xylometazoline in the common cold". American journal of rhinology 22 (5): 491–496. doi:10.2500/ajr.2008.22.3202. PMID 18655753.
- ^ Haenisch, B.; Walstab, J.; Herberhold, S.; Bootz, F.; Tschaikin, M.; Ramseger, R.; Bönisch, H. (2009). "Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline". Fundamental & clinical pharmacology 24 (6): 729–739. doi:10.1111/j.1472-8206.2009.00805.x. PMID 20030735.
- ^ Gold Standard Clinical Pharmacology
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