Acrivastine

Acrivastine

Systematic (IUPAC) name
(E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridin-2-yl}prop-2-enoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682619
Pregnancy cat.	B(US)
Legal status	℞-only (US)
Routes	oral
Pharmacokinetic data
Half-life	1.5 hours
Excretion	Renal
Identifiers
CAS number	87848-99-5 N
ATC code	R06AX18
PubChem	CID 5284514
ChemSpider	4447574 Y
UNII	A20F9XAI7W Y
KEGG	D02760 Y
ChEMBL	CHEMBL1224 Y
Chemical data
Formula	C22H24N2O2
Mol. mass	348.438 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+ Y Key:PWACSDKDOHSSQD-IUTFFREVSA-N Y
N(what is this?)  (verify)

Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine and works by blocking Histamine H1 receptors.

It is sold under the brand name Benadryl Allergy Relief in the U.K. by McNeil Laboratories, not to be confused with Benadryl Once a Day, which is cetirizine and is also sold by McNeil in the U.K. It is available as an over-the-counter medication in the UK.

In the U.S., acrivastine is the active ingredient in the Semprex-D brand. Semprex-D is also acrivastine-based, but contains a decongestant, pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals LLC.

Comparisons with other popular antihistamines

Unlike cetirizine or loratadine, the standard dosage of which is one tablet every day, a single acrivastine tablet may be taken up to three times a day.. This can make it substantially more expensive than cetirizine or loratadine. Additionally, acrivastine is taken as a capsule, where as cetirizine and loratadine are usually sold as tablets.