Carteolol
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| Systematic (IUPAC) name |
| (RS)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one |
| Clinical data |
| Trade names |
Ocupress |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
| MedlinePlus |
a601078 |
| Pregnancy cat. |
C(US) |
| Legal status |
℞ Prescription only |
| Routes |
Eye drops |
| Pharmacokinetic data |
| Bioavailability |
85% |
| Metabolism |
Hepatic, active with 8-hydrocarteolol |
| Half-life |
6–8 hours |
| Excretion |
Renal (50-70%) |
| Identifiers |
| CAS number |
51781-06-7 |
| ATC code |
C07AA15 S01ED05 |
| PubChem |
CID 2583 |
| DrugBank |
APRD00195 |
| ChemSpider |
2485  Y |
| UNII |
8NF31401XG Y |
| KEGG |
D07624 Y |
| ChEBI |
CHEBI:3437 Y |
| ChEMBL |
CHEMBL839 Y |
| Chemical data |
| Formula |
C16H24N2O3 |
| Mol. mass |
292.373 g/mol |
| SMILES |
eMolecules & PubChem |
- InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20) Y
Key:LWAFSWPYPHEXKX-UHFFFAOYSA-N Y
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 Y(what is this?) (verify)
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Carteolol (trade names Cartrol, Ocupress, Teoptic, Arteolol, Arteoptic, Calte, Cartéabak, Carteol, Cartéol, Cartrol, Elebloc, Endak, Glauteolol, Mikelan, Poenglaucol, Singlauc) is a non-selective beta blocker used to treat glaucoma.
[edit] References
[edit] External links
- El-Kamel A, Al-Dosari H, Al-Jenoobi F (2006). "Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride.". Drug Deliv 13 (1): 55–9. doi:10.1080/10717540500309073. PMID 16401594.
- Kuwahara K, Oizumi N, Fujisawa S, Tanito M, Ohira A (2005). "Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro.". Cornea 24 (2): 213–20. doi:10.1097/01.ico.0000141232.41343.9d. PMID 15725891.
- Trinquand C, Romanet J, Nordmann J, Allaire C (2003). "[Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study]". J Fr Ophtalmol 26 (2): 131–6. PMID 12660585.
| v · d · eAdrenergics |
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| Receptor ligands |
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Agonists: 5-FNE • 6-FNE • Amidephrine • Anisodamine • Anisodine • Cirazoline • Dipivefrine • Dopamine • Ephedrine • Epinephrine (Adrenaline) • Etilefrine • Ethylnorepinephrine • Indanidine • Levonordefrin • Metaraminol • Methoxamine • Methyldopa • Midodrine • Naphazoline • Norepinephrine (Noradrenaline) • Octopamine • Oxymetazoline • Phenylephrine • Phenylpropanolamine • Pseudoephedrine • Synephrine • Tetrahydrozoline
Antagonists: Abanoquil • Adimolol • Ajmalicine • Alfuzosin • Amosulalol • Arotinolol • Atiprosin • Benoxathian • Buflomedil • Bunazosin • Carvedilol • CI-926 • Corynanthine • Dapiprazole • DL-017 • Domesticine • Doxazosin • Eugenodilol • Fenspiride • GYKI-12,743 • GYKI-16,084 • Indoramin • Ketanserin • L-765,314 • Labetalol • Mephendioxan • Metazosin • Monatepil • Moxisylyte (Thymoxamine) • Naftopidil • Nantenine • Neldazosin • Nicergoline • Niguldipine • Pelanserin • Phendioxan • Phenoxybenzamine • Phentolamine • Piperoxan • Prazosin • Quinazosin • Ritanserin • RS-97,078 • SGB-1,534 • Silodosin • SL-89.0591 • Spiperone • Talipexole • Tamsulosin • Terazosin • Tibalosin • Tiodazosin • Tipentosin • Tolazoline • Trimazosin • Upidosin • Urapidil • Zolertine
* Note that many TCAs, TeCAs, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole all antagonize α1-adrenergic receptors as well, which contributes to their side effects such as orthostatic hypotension.
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