The Wayback Machine - https://web.archive.org/web/20111115211559/http://en.wikipedia.org/wiki/Setiptiline

Setiptiline

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Setiptiline
Systematic (IUPAC) name
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status ℞ Prescription only
Routes Oral
Identifiers
CAS number 0057262-94-9
ATC code None
PubChem CID 5205
ChemSpider 5016 YesY
UNII 7L38105Z6E YesY
KEGG D08511 YesY
Chemical data
Formula C19H19N 
Mol. mass 261.36 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Setiptiline (Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.[1][2]

Contents

[edit] Chemistry

Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-aza-mianserin.

[edit] Pharmacology

Setiptiline acts as a norepinephrine reuptake inhibitor,[3] α2-adrenergic receptor antagonist,[4] and serotonin receptor antagonist,[5] likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.[3]

[edit] See also

[edit] References

  1. ^ Buschmann,H.; Torrens,A.; Vela,J.M. (2007). Antidepressants, antipsychotics, anxiolytics: from chemistry and pharmacology to clinical application. Wiley VCH. p. 248. ISBN 978-3-527-31058-6. http://books.google.com/books?id=yXD4QA-Y_Z0C&pg=PA248#v=onepage&q=&f=false. 
  2. ^ Swiss Pharmaceutical Society, ed (2000). Index nominum 2000: international drug directory. Medpharm Scientific Publishers. p. 942. ISBN 3-88763-075-0. http://books.google.com/books?id=5GpcTQD_L2oC&pg=PA942#v=onepage&f=false. 
  3. ^ a b Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). "Pharmacological properties of MO-8282, a novel antidepressant". Nihon yakurigaku zasshi. Folia pharmacologica Japonica 88 (4): 309–320. PMID 3792961.  edit
  4. ^ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H. et al. (1986). "Pharmacological studies of MO-8282, a new antidepressant". Nihon yakurigaku zasshi. Folia pharmacologica Japonica 88 (6): 457–466. PMID 2881854.  edit
  5. ^ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). "The lack of antidepressant properties and a potent central antiserotonin activity of Org 8282". Polish journal of pharmacology and pharmacy 38 (4): 377–384. PMID 3774630.  edit


v · d · eAnxiolytics (N05B)
GABAA PAMs
Others
α2δ VDCC Blockers
5-HT1A Agonists
Azapirones: Buspirone • Gepirone • Tandospirone; Others: Flesinoxan • Oxaflozane
H1 Antagonists
Diphenylmethanes: Captodiame • Hydroxyzine; Others: Brompheniramine • Chlorpheniramine • Pheniramine
CRH1 Antagonists
NK2 Antagonists
MCH1 antagonists
mGluR2/3 Agonists
mGluR5 NAMs
TSPO agonists
σ1 agonists
Others
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)
v · d · eTricyclics
Classes
Antidepressants
7-OH-Amoxapine • Amezepine • Amineptine • Amitriptyline • Amitriptylinoxide • Amoxapine • Aptazapine • Azepindole • Azipramine • Butriptyline • Cianopramine • Ciclazindol • Ciclopramine • Clomipramine • Cotriptyline • Cyanodothiepin • Demexiptiline • Depramine/Balipramine • Desipramine • Dibenzepin • Dimetacrine • Dosulepin/Dothiepin • Doxepin • Enprazepine • Esmirtazapine • Fluotracen • Hepzidine • Homopipramol • Imipramine • Imipraminoxide • Intriptyline • Iprindole • Ketipramine • Litracen • Lofepramine • Losindole • Loxapine • Maprotiline • Mariptiline • Mazindol • Melitracen • Metapramine • Mezepine • Mianserin • Mirtazapine • Naranol • Nitroxazepine • Nortriptyline • Noxiptiline • Octriptyline • Opipramol • Oxaprotiline • Pipofezine • Pirandamine • Propizepine • Protriptyline • Quinupramine • Setiptiline/Teciptiline • Tandamine • Tampramine • Tianeptine • Tienopramine • Trimipramine
Antihistamines
Antipsychotics
Acetophenazine • Amoxapine • Asenapine • Butaclamol • Butaperazine • Carphenazine • Carpipramine • Chlorpromazine • Chlorprothixene • Ciclindole • Clocapramine • Clomacran • Clotiapine • Clozapine • Flucindole • Fluotracen • Flupentixol • Fluphenazine • Gevotroline • Homopipramol • Levomepromazine/Methotrimeprazine • Loxapine • Maroxepin • Mesoridazine • Metitepine/Methiothepin • Metoxepin • Mosapramine • Naranol • Olanzapine • Perazine • Perphenazine • Periciazine • Piperacetazine • Pipotiazine • Piquindone • Prochlorperazine • Promazine • Prothipendyl • Quetiapine • Sulforidazine • Thiethylperazine • Thiopropazate • Thioridazine • Thiothixene • Trifluoperazine • Triflupromazine • Zotepine • Zuclopenthixol
Others


Stub icon This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/w/index.php?title=Setiptiline&oldid=455958077"
Personal tools
Namespaces
Variants
Actions
Navigation
Interaction
Toolbox
Print/export
Languages
Morty Proxy This is a proxified and sanitized view of the page, visit original site.