EMR3
| Egf-like module containing, mucin-like, hormone receptor-like 3 | ||||||||
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| Identifiers | ||||||||
| Symbol | EMR3 | |||||||
| External IDs | OMIM: 606101 HomoloGene: 50009 IUPHAR: EMR3 GeneCards: EMR3 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 84658 | n/a | ||||||
| Ensembl | ENSG00000131355 | n/a | ||||||
| UniProt | Q9BY15 | n/a | ||||||
| RefSeq (mRNA) | NM_032571.3 | n/a | ||||||
| RefSeq (protein) | NP_115960.2 | n/a | ||||||
| Location (UCSC) | Chr 19: 14.73 – 14.79 Mb |
n/a | ||||||
| PubMed search | [1] | n/a | ||||||
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein that in humans is encoded by the EMR3 gene.[1]
Contents |
[edit] Function
The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. In the case of EMR3, the N-terminal protein domains consists of 2 epidermal growth factor (EGF)-like domains. [2] [3] EMR3 is expressed predominantly by cells of the immune system. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 EMR2 on chromosome 19. The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[4]
[edit] See also
[edit] References
- ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (May 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J Biol Chem 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
- ^ Yona, Stacey (2011). Adhesion-GPCRs. Springer. pp. 1-200. ISBN 978-1-4419-7912-4.
- ^ Yona, S; Lin, HH; Siu, WO; Gordon, S; Stacey, M (2008 Oct). "Adhesion-GPCRs: emerging roles for novel receptors.". Trends in biochemical sciences 33 (10): 491-500. PMID 18789697.
- ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658.
[edit] Further reading
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Matmati M, Pouwels W, van Bruggen R, et al. (2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". J. Leukoc. Biol. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056.
- Kane AJ, Sughrue ME, Rutkowski MJ, Phillips JJ, Parsa AT (November 2010). "EMR3: A Potential Mediator of Invasive Phenotypic Variation in Glioblastoma and Novel Therapeutic Target". Neuroreport 21 (16): 1018–22. doi:10.1097/WNR.0b013e32833f19f2. PMC 3064464. PMID 20827226. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3064464/.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
