Six prominent citizens of Bizarroville have disappeared whilst attending a party held by the devious Dr. Dudley Dabble. Our hero, Rave, therefore heads over to Dr. Dabble's spooky mansion, which is haunted by Lydia Novella, the ghost of a famous writer. Playing as Rave and with Lydia as your Exposition Fairy, your goal is to complete a series of Fetch Quests that will enable you to rescue the missing guests from Dr. Dabble's latest invention.

This game is something of a Continuity Reboot for the Blaster Mystery series. It only loosely follows the previous game, Math Blaster Mystery: The Great Brain Robbery, but its own canon (mostly) continues into the next two games. In particular, this game introduces the six Bizarroville citizens who serve as the supporting cast of the series from this point on.

This game provides examples of:

• Alphabet Soup Cans: A ubiquitous trope in the Blaster games, of course, but this one provides a slight justification for it. In Dr. Dabble's diary, he states that he set up "word traps" around the house because they would be a suitable distraction for Lydia, what with her being the ghost of a famous writer.
• Bananas Are Funny: In the living room, there's a book that describes Bizarroville's annual Have-A-Banana festival and its wacky celebrations of "all things banana."
• Brand X: According to Dr. Dabble's yearbook, a young Gloria Ghastly was hoping to someday win the "World's Best Actress award," which is presumably nothing like the Academy Award for Best Actress. Also, one of the fortune cookie puzzles mentions her desire to be nominated for the "Best Actress in a Horror Picture" award.
• Celeb Crush: Rave apparently has one on Gloria Ghastly. In the opening scene, he has one of her movie posters on his refrigerator, and he screams when he hears that she's disappeared. Later on, when Gloria thanks Rave for saving her, he's shown looking very smitten.
• Chicken Joke: The yearbook quotes Gorky Barf saying, "Why did the chicken cross the road? Uh, I forgot the punchline."
• Cool Shades: Worn by Gloria Ghastly. One of her items is "a pair of her signature dark sunglasses." The yearbook quotes her saying, "a girl can never have too many pairs of sunglasses."
• Denial of Animality: Dr. Dabble's new invention is described as changing his victims from "human beings" into household appliances. This is despite the fact that everyone living in this universe is some kind of Halloweenish creature.
• Evil Laugh: Done by Lydia when you quit the game, despite her not actually being a villain.
• Extremely Overdue Library Book: One of the fortune cookie puzzles reveals that Gorky Barf is still missing a library book that Dr. Dabble checked out 26 years ago.
• Fetch Quest: In each round, you collect up to six pieces of evidence. Three of these are needed to rescue a guest, and the other three are red herrings. To find out which three items you actually need, you have to additionally collect three clues.
• Forced Transformation: The six missing guests were turned into household appliances.
• Friends Turned Romantic Rivals: Back in high school, Lou Fright and Dudley Dabble were best friends up until they both liked Bobbi Sax.
• Gender-Equal Ensemble: The six guests consist of three males and three females.
• Green Aesop: By implication. Good guy Lou Fright specializes in eco-friendly inventions, much to the contempt of his villainous foil, Dr. Dabble.
• Haunted House: Dr. Dabble's mansion is haunted by the ghost of nineteenth-century writer Lydia Novella, who lived there when she was alive. Other ghosts are also seen during the catacombs game.
• High-School Sweethearts: Lou and Bobbi Fright were lovers back in high school and are now Happily Married.
• Idiot Ball: Despite being the ghost of a famous writer, Lydia makes fairly regular mistakes in the sentence spinner game, which teaches basic grammar.
• Karma Houdini: Although you rescue all six guests, Dr. Dabble receives no comeuppance in this game, unless you count him seeing his scheme thwarted. Given how closely this game and Math Blaster: Pre-Algebra seem to have been developed in conjunction with each other, it's possible Dabble's defeat was simply being saved for the next game.
• Late to the Tragedy: As Rave, you're investigating what happened the night of Dr. Dabble's party, with some of the information incorporated into the educational mini-games.
• Love Triangle: Back in high school, Lou Fright and Dudley Dabble vied for the affections of Bobbi Sax. As evidenced by her last name in the present day, she chose Lou.
• Luck-Based Mission: The sentence spinner game. With random whammies like "wordrupt" (a pun on "bankrupt" that's exactly what it sounds like), you can easily lose without making a single mistake. It'll certainly be worse for you if you do make mistakes, but still, the game is mostly pure chance.
• Mad Scientist Laboratory: Each mission concludes in Dr. Dabble's secret lab, where you throw his dehumanizer machine into reverse to rescue one of the party guests.
• Manly Tears: In Coach Lilliput's newspaper story, he describes how he was turned into a pitching machine, with baseballs shooting out of his nostrils, bellybutton, and mouth. He notes that, "I almost started crying, but then again, who wouldn't in my situation?"
• Millennium Bug: The game suffers from a version of this. The player's records are dated with the year given as two digits, but years after 2000 are represented with a "1" in front, so 2001 would be rendered as 101.
• Mind Screw: Lydia's diary, written as if she were a teen alive in 1995, when the game establishes she actually died in 1847. She's then haunted by herself.
• Never My Fault: It is revealed, after you save them, that each of Dr. Dabble's victims are acquaintances from his younger days whom he feels have done him wrong in some way and that he had a score to settle with, even though said wrongs he suffered he (usually) really deserved.
• New Work, Recycled Graphics: In the book describing Bizarroville's Have-A-Banana festival, the accompanying illustration is recycled from one of the spaceship commercial animations in Reading Blaster 2000.
• No Ending: Lydia's journal ends on a cliffhanger with no resolution whatsoever.
• Not Good with Rejection: This was the reason why Dr. Dabble spirited away Bobbi Fright: he wanted to be her boyfriend, but she kept refusing, while he would not take no for an answer.
• Objectshifting: Dr. Dabble kidnaps six people and transforms them into household appliances as revenge for (often insignificant) past slights against him.
• Older Than They Look: Apart from Rave, most of the characters fall under this category. Gloria Ghastly is confirmed to be 96 years old, and recalls Dr. Dabble bothering her when they were still children, meaning he's around her age despite resembling a middle-aged human. Mayor O'Cassidy and the Frights are also in the same boat since they attended high school the same time he did. Coach Lilliput and Gorky Barf take the cake for being centenarians, full-grown adults when Dabble was still a young boy.
• Playing a Tree: Gloria Ghastly's yearbook entry mentions that, as part of the drama club, she played the breadcrumb in Hansel and Gretel.
• Produce Pelting: Gorky Barf's newspaper story mentions that he once suffered a "rotten tomato overdose" during his failed stand-up career. Apparently, they don't care for knock-knock jokes in Vegas.
• Red Herring: In each round, there are three pieces of evidence that you don't need, including items belonging to Dr. Dabble and Lydia rather than any of the guests. Additionally, the game sometimes makes it unintuitive which items go with which guest in order to ensure that you read the clues like you're supposed to. For instance, you'd think the pearl necklace would belong to movie star Gloria Ghastly, and the football would belong to Coach Gulliver Lilliput, but you'd be wrong. It turns out the necklace belongs to the coach's mother, and the football belongs to Gloria because it's a signed movie prop.
• Revenge: Dr. Dabble's motivation is getting revenge against his "greatest enemies," as he calls them.
• Screw the Rules, I Have Connections!: Jackie O'Cassidy's newspaper story recounts how, back in high school, she won the race for class president by going to her mother, who was then the mayor. In order to persuade a young Dudley Dabble to drop out of the race, Jackie's mother had a skunk refuge built next to the Dabbles' house, their driveway connected to an airport runway, and a freeway built through Dudley's own bedroom. Jackie might be the only guest who fully deserved Dabble's revenge.
• Shout-Out:
  • Coach Gulliver Lilliput's name is a reference to Gulliver and the Lilliputians from Gulliver's Travels. Gorky Barf is likewise named after Gorky Park.
  • The schematic for Dr. Dabble's new invention is labeled "Plan 9."
  • The newspaper includes an advertisement for Funny Ghoul starring Babbles Stystand and Ogre Scareief.
  • One of Gloria Ghastly's items is a football signed by Newt Rocky Knees.
• Stealth Insult: Dr. Dabble mentions that the mayor may have fewer ethics than he does and turns her into a vacuum cleaner. He thinks she sucks.
• Stopped Clock: According to Lydia's obituary, the Novella family clock mysteriously stopped ticking at the moment of her death.
• The Triple: Gorky Barf recounts his days as a stand-up comic: "I performed everywhere: Vegas, Atlantic City, Ypsilanti..."
• A True Story in My Universe: Gloria Ghastly's newspaper story mentions that she's received an offer to star in a movie based on the events of this game.
• The Voice: Lydia the Ghost is a disembodied voice occasionally represented by floating objects. In the sentence spinner game, a pair of disembodied feminine eyes serve as her avatar while your avatar is a picture of Rave.