A Police Procedural revolving around an Odd Couple of crime-solving brothers. Don Eppes (Rob Morrow) heads a team of FBI investigators called on to solve the exceptionally sensitive and baffling crimes that happen in Los Angeles about once a week. To solve these highly complex crimes, he invariably turns to his brother, Charlie (David Krumholtz), a college professor and mathematical prodigy, who applies pure mathematics to the task of solving crimes.
Ultimately, math conquers all... although on the way, Charlie usually faces a crisis of faith stemming from the fact that, while he's a mathematical genius, he is also emotionally immature, with only a very slight understanding of human motivation. Balance is restored via the assistance of his father Alan (Judd Hirsch, a veteran of three other TV series produced by Paramount) and physicist colleague Larry (Peter MacNicol). Larry generally advises him to steer clear of messy human-interaction problems, while Alan nudges him toward a better understanding of human nature.
It has the tie-in The Numbers Behind Numb3rs: Solving Crime with Mathematics.
The show finished its sixth and final season in 2010.
The show's storylines were supposedly inspired by actual cases.