Generally, if writers want to remove a character from their ensemble, they will either kill that character off or put them on a bus (or both) to explain their absence. Sufferers of Chuck Cunningham Syndrome, on the other hand, simply disappear into limbo. One day they will walk out of a scene, and just... never walk back in. They will often be retconned right out of the story's history, and everyone still left onscreen will simply carry on as if the character never existed or had any impact on the story.
This is sometimes caused by the writer[s] gradually losing interest in the character and, without making a conscious decision to remove them, eventually forgetting about them entirely. More often, complications behind the scenes drive the decision to remove a character. Sometimes, the character being removed may also be because the actor has died. Alternatively, the character may not have had an important role despite being part of the main cast; in other words, being a Satellite Character or Flat Character.
The Trope Namer is Chuck, who was Richie and Joanie Cunningham's older brother in the first two seasons of Happy Days. Remember him? No? Neither did the show. In later seasons, both Cunningham parents said they only had two children and Chuck was wiped from existence. With Fonzie becoming a main character by the second season, and now firmly in the big brother role for Richie, the little-used Chuck wasn't needed.
A closely related slang term (and an alternate name for the trope) is "Mandyville" (or "Mandyland") — a reference to Mandy Hampton, a supporting character played by Moira Kelly on the first season of The West Wing, who was inexplicably never seen again after Season 1 ended. In reality, Kelly and series creator Aaron Sorkin came to a mutual agreement that the character wasn't gelling with the rest of the cast, and agreed that she wouldn't be returning for Season 2. But when Sorkin didn't bother to write in an in-universe explanation for her absence, fans joked that Mandy caught a bus bound for "Mandyville", said to be the home of all television characters who vanish without explanation.
Over the years, as media has become more meta, playful references to the ignominiously departed have become common, either as lampshades within the series itself or in parodies or satires of it.
A subtrope of Un-person, although this isn't necessarily intentional. When this happens in-universe, with the character having their existence literally erased, it's a Ret-Gone. What Happened to the Mouse? is this trope for minor aspects like side characters or subplots. Absent Animal Companion applies this (in most cases) to pets and/or animals that disappear once their plot relevance is gone. Sequel Non-Entity is a subtrope concerned with a character not returning for a sequel in particular, rather than vanishing from a series as a whole — though this can develop into full-blown Chuck Cunningham Syndrome if they inexplicably never return in later sequels either.
This trope is only applicable to genuine members of the ensemble who would otherwise seem to be a little more permanent, not characters who appear for one or two episodes and disappear just as swiftly. For characters who are specifically brought in only for a one-shot purpose, see Long-Lost Uncle Aesop. If a character appears in the pilot or very early episode of a show and then vanishes it may be a case of Early-Installment Weirdness.
For characters who are written out of the main story but are still hanging around in view, see Demoted to Extra. Also see Out of Focus (when a character has slipped from view but is not quite forgotten — again, this can morph into full CCS if they never get brought back into focus...), and Shoo Out the New Guy (where a character gets at least an excuse in the show for disappearing). For characters that are given a reason for their departure and an onscreen send-off, see Put on a Bus. See Disposable Love Interest for when this happens to a one-off love interest.
Present Absence is when this trope is avoided and a character's absence is not only noticed in-story, but is often a major driver of the plot. Compare Forgotten Fallen Friend, where a character is absent due to being deceased, but despite their connection to the other characters is no longer acknowledged. See also Written-In Absence, where a character momentarily vanishes due to their actor being unavailable and the production team works around it by providing an in-universe explanation for the character not being present.
Contrast with Remember the New Guy?, where someone comes in out of nowhere midway through a series yet everyone acts as though they've been there the whole time. Similar in spirit to The Other Darrin, wherein a character's actor or voice is replaced and nobody in-universe seems to notice or care — ironically Chuck Cunningham himself suffered from this as well, since he was played by two different actors: Gavin O'Herlihy in season 1 & Randolph Roberts in season 2.
Not to be confused with anyone real who has the last name "Cunningham".
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