Klaritromicin

Klaritromicin
Klinički podaci
Prodajno ime	Biaxin, Biaxin XL, Klacid, Klaricid
Drugs.com	Monografija
Način primene	Oralno
Identifikatori
CAS broj	81103-11-9
ATC kod	J01FA09 (WHO)
PubChem	CID 5284534
DrugBank	DB01211
ChemSpider	21112273
KEGG	C06912
ChEBI	CHEBI:3732
ChEMBL	CHEMBL1741

Klaritromicin je organsko jedinjenje, koje sadrži 38 atoma ugljenika i ima molekulsku masu od 747,953 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	14
Broj donora vodonika	4
Broj rotacionih veza	8
Particioni koeficijent^[9] (ALogP)	2,2
Rastvorljivost^[10] (logS, log(mol/L))	-5,4
Polarna površina^[11] (PSA, Å²)	182,9

Reference

^ Malhotra-Kumar S, Lammens C, Coenen S, Van Herck K, Goossens H: Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet. 10;Malhotra-Kumar, Surbhi; Lammens, Christine; Coenen, Samuel; Van Herck, Koen; Goossens, Herman (2007 Feb). . „Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: A randomised, double-blind, placebo-controlled study”. Lancet. 369 (9560): 482—90. PMID 17292768. doi:10.1016/S0140-6736(07)60235-9. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Zuckerman JM, Qamar F, Bono BR. Zuckerman, Jerry M.; Qamar, Fozia; Bono, Bartholomew R. (2009 Dec). . „Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline”. Infect Dis Clin North Am. 23 (4): 997—1026. PMID 19909895. doi:10.1016/j.idc.2009.06.013. Проверите вредност парамет(а)ра за датум: |date= (помоћ), ix-x.
^ Piscitelli SC, Danziger LH, Rodvold KA. . „Clarithromycin and azithromycin: new macrolide antibiotics”. Clin Pharm. 11 (2): 137—52. 1992 Feb. PMID 1312921. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Peters DH, Clissold SP: Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Peters, David H.; Clissold, Stephen P. (1992 Jul). . „Clarithromycin”. Drugs. 44 (1): 117—64. PMID 1379907. doi:10.2165/00003495-199244010-00009. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Clarithromycin. Tuberculosis (Edinb). . . 88 (2): 92—5. 2008 Mar. PMID 18486039. Проверите вредност парамет(а)ра за датум: |date= (помоћ); Недостаје или је празан параметар |title= (помоћ)
^ Stephenson GA, Stowell JG, Toma PH, Pfeiffer RR, Byrn SR. Stephensonx, Gregory A.; Stowell, Oseph G.; Toma, Pascal H.; Pfeiffer, Ralph R.; Byrn, Stephen R. (1997 Nov). . „Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity”. J Pharm Sci. 86 (11): 1239—44. Bibcode:1997JPhmS..86.1239S. PMID 9383733. doi:10.1021/js9701667. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Clarithromycin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

Portali:

Klaritromicin na srodnim projektima Vikipedije:

Mediji na Ostavi

Podaci na Vikipodacima

[1] Malhotra-Kumar S, Lammens C, Coenen S, Van Herck K, Goossens H: Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet. 10;Malhotra-Kumar, Surbhi; Lammens, Christine; Coenen, Samuel; Van Herck, Koen; Goossens, Herman (2007 Feb). . „Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: A randomised, double-blind, placebo-controlled study”. Lancet. 369 (9560): 482—90. PMID 17292768. doi:10.1016/S0140-6736(07)60235-9. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Zuckerman JM, Qamar F, Bono BR. Zuckerman, Jerry M.; Qamar, Fozia; Bono, Bartholomew R. (2009 Dec). . „Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline”. Infect Dis Clin North Am. 23 (4): 997—1026. PMID 19909895. doi:10.1016/j.idc.2009.06.013. Проверите вредност парамет(а)ра за датум: |date= (помоћ), ix-x.

[3] Piscitelli SC, Danziger LH, Rodvold KA. . „Clarithromycin and azithromycin: new macrolide antibiotics”. Clin Pharm. 11 (2): 137—52. 1992 Feb. PMID 1312921. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Peters DH, Clissold SP: Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Peters, David H.; Clissold, Stephen P. (1992 Jul). . „Clarithromycin”. Drugs. 44 (1): 117—64. PMID 1379907. doi:10.2165/00003495-199244010-00009. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Clarithromycin. Tuberculosis (Edinb). . . 88 (2): 92—5. 2008 Mar. PMID 18486039. Проверите вредност парамет(а)ра за датум: |date= (помоћ); Недостаје или је празан параметар |title= (помоћ)

[6] Stephenson GA, Stowell JG, Toma PH, Pfeiffer RR, Byrn SR. Stephensonx, Gregory A.; Stowell, Oseph G.; Toma, Pascal H.; Pfeiffer, Ralph R.; Byrn, Stephen R. (1997 Nov). . „Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity”. J Pharm Sci. 86 (11): 1239—44. Bibcode:1997JPhmS..86.1239S. PMID 9383733. doi:10.1021/js9701667. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[7] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[8] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[9] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[10] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[11] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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