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Review
. 2023 Aug 20;136(16):1923-1928.
doi: 10.1097/CM9.0000000000002771. Epub 2023 Jul 14.

Post-tuberculosis lung disease and chronic obstructive pulmonary disease

Affiliations

Affiliations

  • 1 Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Center for Chronic Airway Diseases, Peking University Health Science Center, Peking University, Beijing 100191, China.
  • 2 Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa.
Review

Post-tuberculosis lung disease and chronic obstructive pulmonary disease

Xiaoyan Gai et al. Chin Med J (Engl). .
. 2023 Aug 20;136(16):1923-1928.
doi: 10.1097/CM9.0000000000002771. Epub 2023 Jul 14.

Affiliations

  • 1 Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Center for Chronic Airway Diseases, Peking University Health Science Center, Peking University, Beijing 100191, China.
  • 2 Division of Pulmonology, Department of Medicine, Stellenbosch University & Tygerberg Academic Hospital, Cape Town, South Africa.

Abstract

The burden of chronic airway diseases, including chronic obstructive pulmonary disease (COPD), continues to increase, especially in low- and middle-income countries. Post-tuberculosis lung disease (PTLD) is characterized by chronic lung changes after the "cure" of pulmonary tuberculosis (TB), which may be associated with the pathogenesis of COPD. However, data on its prevalence, clinical manifestations, computed tomography features, patterns of lung function impairment, and influencing factors are limited. The pathogenic mechanisms underlying PTLD remain to be elucidated. This review summarizes the recent advances in PTLD and TB-associated COPD. Research is urgently needed both for the prevention and management of PTLD.

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Conflict of interest statement

None.

Figures

Figure 1

Figure 1

Chest CT scans of tuberculosis…

Figure 1

Chest CT scans of tuberculosis sequelae in two COPD patients with a history…

Figure 1
Chest CT scans of tuberculosis sequelae in two COPD patients with a history of cigarette smoking. Extensive emphysema and a calcified lesion (A, B) and emphysema and scarred lesions with bronchiectatic changes (C, D) in the right upper lobe. COPD: Chronic obstructive pulmonary disease; CT: Computed tomography.
Figure 2

Figure 2

The interaction between PTLD and…

Figure 2

The interaction between PTLD and CS in TB-associated COPD. Mtb infection leads to…

Figure 2
The interaction between PTLD and CS in TB-associated COPD. Mtb infection leads to active pulmonary TB, which may cause post-TB lung disease even after therapy in susceptible hosts. CS serves as a risk factor for Mtb infection and severe lung disease, and plays a critical role in TB-associated COPD. COPD: Chronic obstructive pulmonary disease; CS: Cigarette smoke; MMP: Matrix metalloproteinase; Mtb: Mycobacterium tuberculosis; PTLD: Post-tuberculosis lung disease; TB: Tuberculosis; TB-COPD: TB-associated COPD.

References

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    1. Allwood BW van der Zalm MM Amaral AFS Byrne A Datta S Egere U, et al. Post-tuberculosis lung health: Perspectives from the First International Symposium. Int J Tuberc Lung Dis 2020;24: 820–828. doi: 10.5588/ijtld.20.0067. - PubMed
    1. van Kampen SC Wanner A Edwards M Harries AD Kirenga BJ Chakaya J, et al. International research and guidelines on post-tuberculosis chronic lung disorders: A systematic scoping review. BMJ Glob Health 2018;3: e000745. doi: 10.1136/bmjgh-2018-000745. - PMC - PubMed
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