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. 2016:2016:1423131.
doi: 10.1155/2016/1423131. Epub 2016 Oct 20.

Adalimumab Induced or Provoked MS in Patient with Autoimmune Uveitis: A Case Report and Review of the Literature

Rana Alnasser Alsukhni  1 , Ziena Jriekh  2 , Yasmin Aboras  1
Affiliations

Affiliations

  • 1 Division of Neurology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.
  • 2 Division of Rheumatology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.

Adalimumab Induced or Provoked MS in Patient with Autoimmune Uveitis: A Case Report and Review of the Literature

Rana Alnasser Alsukhni et al. Case Rep Med. 2016.
. 2016:2016:1423131.
doi: 10.1155/2016/1423131. Epub 2016 Oct 20.

Authors

Rana Alnasser Alsukhni  1 , Ziena Jriekh  2 , Yasmin Aboras  1

Affiliations

  • 1 Division of Neurology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.
  • 2 Division of Rheumatology, Department of Internal Medicine, Aleppo University Hospital, Aleppo, Syria.

Abstract

Anti-tumor necrosis factor α (anti-TNF-α) agents have been widely used in the field of autoimmune diseases and have proved decisive efficacy and relative safety. Data concerning their adverse effects has been lately describing central nervous system (CNS) demyelination process at escalating basis. Case Presentation. A 23-year-old male with autoimmune uveitis and a family history of multiple sclerosis (MS) developed two neurological attacks, after Adalimumab infusion, simultaneously with several cerebral lesions on magnetic resonance imaging (MRI). Hence the diagnosis of Adalimumab induced MS was suspected. Conclusion. This case is reported to tell physicians to be cautious when using anti-TNF-α in patients with family history of MS and to reconsider the risk of MS in patients with autoimmune diseases.

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Figures

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Figure 1

(a, b, c, and d)…

Figure 1

(a, b, c, and d) Flair MRI slices (axial and coronal slices) show…

Figure 1
(a, b, c, and d) Flair MRI slices (axial and coronal slices) show periventricular and juxtacortical high intensity lesions. (e) Axial T2 MRI shows multiple juxtacortical high intensity lesions. (f) Sagittal T2 MRI of the cervical spinal cord shows T2 hyperintense lesion at the level of C4.
Figure 2

Figure 2

(a and b) Axial T2…

Figure 2

(a and b) Axial T2 MRI shows multiple periventricular and juxtacortical high intensity…

Figure 2
(a and b) Axial T2 MRI shows multiple periventricular and juxtacortical high intensity lesions. (c) Coronal flair MRI shows periventricular and juxtacortical high intensity lesions.
See this image and copyright information in PMC

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