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. 2010 Sep 8;10(9):3223-30.
doi: 10.1021/nl102184c.

Nanotechnology in drug delivery and tissue engineering: from discovery to applications

Jinjun Shi  1 , Alexander R Votruba, Omid C Farokhzad, Robert Langer
Affiliations

Affiliation

  • 1 MIT-Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Nanotechnology in drug delivery and tissue engineering: from discovery to applications

Jinjun Shi et al. Nano Lett. .
. 2010 Sep 8;10(9):3223-30.
doi: 10.1021/nl102184c.

Authors

Jinjun Shi  1 , Alexander R Votruba, Omid C Farokhzad, Robert Langer

Affiliation

  • 1 MIT-Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of nanomedicine, drug delivery and tissue engineering, highlighting the advances we have recently experienced, the challenges we are currently facing, and what we are likely to witness in the near future.

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Figures

Figure 1

Figure 1

Timeline of nanotechnology-based drug delivery.…

Figure 1

Timeline of nanotechnology-based drug delivery. Here, we highlight some nanoscale delivery systems that…

Figure 1
Timeline of nanotechnology-based drug delivery. Here, we highlight some nanoscale delivery systems that serve as important milestones throughout the history of drug delivery.
Figure 2

Figure 2

Schematic of fabricated nanotopographic features…

Figure 2

Schematic of fabricated nanotopographic features used to guide cell behaviors via cell-nanotopography interactions.

Figure 2
Schematic of fabricated nanotopographic features used to guide cell behaviors via cell-nanotopography interactions.
Figure 3

Figure 3

Nanotechnology applications in engineering complex…

Figure 3

Nanotechnology applications in engineering complex tissues. Cells seeded into biocompatible and nanostructured scaffolds…

Figure 3
Nanotechnology applications in engineering complex tissues. Cells seeded into biocompatible and nanostructured scaffolds are able to reassemble into functional structures that resemble native tissues, under the stimulation of growth factors spatiotemporally delivered by nanoparticles. Complex tissues, like this lobule of the liver, could be engineered with the help of devices that are equipped with nanotechnology.
See this image and copyright information in PMC

References

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