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. 2005 Jul;6 Spec No(Suppl 1):S20-4.
doi: 10.1038/sj.embor.7400426.

Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients

Affiliations

Affiliation

  • 1 The Children's Hospital Oakland Research Institute, Oakland, CA, USA. bames@chori.org

Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients

Bruce N Ames. EMBO Rep. 2005 Jul.
. 2005 Jul;6 Spec No(Suppl 1):S20-4.
doi: 10.1038/sj.embor.7400426.

Author

Affiliation

  • 1 The Children's Hospital Oakland Research Institute, Oakland, CA, USA. bames@chori.org

Abstract

To maximize human health and lifespan, scientists must abandon outdated models of micronutrients

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Giuseppe Arcimboldo (1573) The Summer , oil…

Giuseppe Arcimboldo (1573) The Summer , oil on canvas. Original: Musée du Louvre, Paris, France.…

Giuseppe Arcimboldo (1573) The Summer, oil on canvas. Original: Musée du Louvre, Paris, France. Image provided by Gerard Le Gall, RMN, Paris, France. With permission from bpk, Berlin, Germany.
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References

    1. Abrams SA (2002) Nutritional rickets: an old disease returns. Nutr Rev 60: 111–115 - PubMed
    1. Ames BN (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475: 7–20 - PubMed
    1. Ames BN, Wakimoto P (2002) Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer 2: 694–704 - PubMed
    1. Ames BN, Elsonschwab I, Silver EA (2002) High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr 75: 616–658 - PubMed
    1. Atamna H, Frey WH 2nd (2004) A role for heme in Alzheimer's disease: heme binds amyloid β and has altered metabolism. Proc Natl Acad Sci USA 101: 11153–11158 - PMC - PubMed

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