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. 2001 Mar 26;11(6):793-5.
doi: 10.1016/s0960-894x(01)00062-2.

A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties

U Laban  1 , D Kurrasch-Orbaugh, D Marona-Lewicka, D E Nichols
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, USA.

A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties

U Laban et al. Bioorg Med Chem Lett. .
. 2001 Mar 26;11(6):793-5.
doi: 10.1016/s0960-894x(01)00062-2.

Authors

U Laban  1 , D Kurrasch-Orbaugh, D Marona-Lewicka, D E Nichols

Affiliation

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, USA.

Abstract

Synthesis and biological evaluation of a novel fluorinated tryptamine analogue are described. This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist.

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