diff --git a/Include/internal/pycore_opcode_metadata.h b/Include/internal/pycore_opcode_metadata.h
index dc7ecc998c4477..203712813807a0 100644
--- a/Include/internal/pycore_opcode_metadata.h
+++ b/Include/internal/pycore_opcode_metadata.h
@@ -1091,7 +1091,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [BINARY_OP_SUBSCR_LIST_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_SUBSCR_LIST_SLICE] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_SUBSCR_STR_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
-    [BINARY_OP_SUBSCR_TUPLE_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
+    [BINARY_OP_SUBSCR_TUPLE_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_SUBTRACT_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG },
     [BINARY_OP_SUBTRACT_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_SLICE] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
@@ -1099,8 +1099,8 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [BUILD_LIST] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_ESCAPES_FLAG },
     [BUILD_MAP] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BUILD_SET] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [BUILD_SLICE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG },
-    [BUILD_STRING] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG },
+    [BUILD_SLICE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
+    [BUILD_STRING] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BUILD_TEMPLATE] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BUILD_TUPLE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG },
     [CACHE] = { true, INSTR_FMT_IX, 0 },
@@ -1196,7 +1196,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [INSTRUMENTED_RETURN_VALUE] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [INSTRUMENTED_YIELD_VALUE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_ESCAPES_FLAG },
     [INTERPRETER_EXIT] = { true, INSTR_FMT_IX, HAS_ESCAPES_FLAG },
-    [IS_OP] = { true, INSTR_FMT_IB, HAS_ARG_FLAG },
+    [IS_OP] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ESCAPES_FLAG },
     [JUMP_BACKWARD] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG | HAS_EVAL_BREAK_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [JUMP_BACKWARD_JIT] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG | HAS_EVAL_BREAK_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [JUMP_BACKWARD_NO_INTERRUPT] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_JUMP_FLAG },
@@ -1205,8 +1205,8 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [LIST_APPEND] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG },
     [LIST_EXTEND] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [LOAD_ATTR_CLASS] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_EXIT_FLAG },
-    [LOAD_ATTR_CLASS_WITH_METACLASS_CHECK] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_EXIT_FLAG },
+    [LOAD_ATTR_CLASS] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
+    [LOAD_ATTR_CLASS_WITH_METACLASS_CHECK] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR_GETATTRIBUTE_OVERRIDDEN] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_DEOPT_FLAG },
     [LOAD_ATTR_INSTANCE_VALUE] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR_METHOD_LAZY_DICT] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
@@ -1216,7 +1216,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [LOAD_ATTR_NONDESCRIPTOR_NO_DICT] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR_NONDESCRIPTOR_WITH_VALUES] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR_PROPERTY] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
-    [LOAD_ATTR_SLOT] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
+    [LOAD_ATTR_SLOT] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_ATTR_WITH_HINT] = { true, INSTR_FMT_IBC00000000, HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_BUILD_CLASS] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [LOAD_COMMON_CONSTANT] = { true, INSTR_FMT_IB, HAS_ARG_FLAG },
@@ -1254,8 +1254,8 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [POP_EXCEPT] = { true, INSTR_FMT_IX, HAS_ESCAPES_FLAG },
     [POP_ITER] = { true, INSTR_FMT_IX, HAS_ESCAPES_FLAG | HAS_PURE_FLAG },
     [POP_JUMP_IF_FALSE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG },
-    [POP_JUMP_IF_NONE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG },
-    [POP_JUMP_IF_NOT_NONE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG },
+    [POP_JUMP_IF_NONE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG | HAS_ESCAPES_FLAG },
+    [POP_JUMP_IF_NOT_NONE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG | HAS_ESCAPES_FLAG },
     [POP_JUMP_IF_TRUE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_JUMP_FLAG },
     [POP_TOP] = { true, INSTR_FMT_IX, HAS_ESCAPES_FLAG | HAS_PURE_FLAG },
     [PUSH_EXC_INFO] = { true, INSTR_FMT_IX, 0 },
@@ -1292,7 +1292,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [TO_BOOL_ALWAYS_TRUE] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [TO_BOOL_BOOL] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG },
     [TO_BOOL_INT] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
-    [TO_BOOL_LIST] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG },
+    [TO_BOOL_LIST] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [TO_BOOL_NONE] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG },
     [TO_BOOL_STR] = { true, INSTR_FMT_IXC00, HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [UNARY_INVERT] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
@@ -1300,8 +1300,8 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[267] = {
     [UNARY_NOT] = { true, INSTR_FMT_IX, HAS_PURE_FLAG },
     [UNPACK_EX] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [UNPACK_SEQUENCE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [UNPACK_SEQUENCE_LIST] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
-    [UNPACK_SEQUENCE_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
+    [UNPACK_SEQUENCE_LIST] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
+    [UNPACK_SEQUENCE_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [UNPACK_SEQUENCE_TWO_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [WITH_EXCEPT_START] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [YIELD_VALUE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG },
diff --git a/Include/internal/pycore_uop_metadata.h b/Include/internal/pycore_uop_metadata.h
index 9b88763da07ba7..a15514cc9622c6 100644
--- a/Include/internal/pycore_uop_metadata.h
+++ b/Include/internal/pycore_uop_metadata.h
@@ -75,7 +75,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_GUARD_NOS_LIST] = HAS_EXIT_FLAG,
     [_GUARD_TOS_LIST] = HAS_EXIT_FLAG,
     [_GUARD_TOS_SLICE] = HAS_EXIT_FLAG,
-    [_TO_BOOL_LIST] = 0,
+    [_TO_BOOL_LIST] = HAS_ESCAPES_FLAG,
     [_TO_BOOL_NONE] = HAS_EXIT_FLAG,
     [_GUARD_NOS_UNICODE] = HAS_EXIT_FLAG,
     [_GUARD_TOS_UNICODE] = HAS_EXIT_FLAG,
@@ -103,7 +103,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_BINARY_OP_SUBSCR_STR_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_GUARD_NOS_TUPLE] = HAS_EXIT_FLAG,
     [_GUARD_TOS_TUPLE] = HAS_EXIT_FLAG,
-    [_BINARY_OP_SUBSCR_TUPLE_INT] = HAS_DEOPT_FLAG,
+    [_BINARY_OP_SUBSCR_TUPLE_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_GUARD_NOS_DICT] = HAS_EXIT_FLAG,
     [_GUARD_TOS_DICT] = HAS_EXIT_FLAG,
     [_BINARY_OP_SUBSCR_DICT] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
@@ -130,8 +130,8 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_DELETE_NAME] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_ESCAPES_FLAG,
     [_UNPACK_SEQUENCE] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_UNPACK_SEQUENCE_TWO_TUPLE] = HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
-    [_UNPACK_SEQUENCE_TUPLE] = HAS_ARG_FLAG | HAS_DEOPT_FLAG,
-    [_UNPACK_SEQUENCE_LIST] = HAS_ARG_FLAG | HAS_DEOPT_FLAG,
+    [_UNPACK_SEQUENCE_TUPLE] = HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
+    [_UNPACK_SEQUENCE_LIST] = HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_UNPACK_EX] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_ATTR] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_DELETE_ATTR] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
@@ -151,7 +151,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_LOAD_DEREF] = HAS_ARG_FLAG | HAS_LOCAL_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_DEREF] = HAS_ARG_FLAG | HAS_FREE_FLAG | HAS_ESCAPES_FLAG,
     [_COPY_FREE_VARS] = HAS_ARG_FLAG,
-    [_BUILD_STRING] = HAS_ARG_FLAG | HAS_ERROR_FLAG,
+    [_BUILD_STRING] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BUILD_INTERPOLATION] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BUILD_TEMPLATE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BUILD_TUPLE] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG,
@@ -173,9 +173,9 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_LOAD_ATTR_INSTANCE_VALUE] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_LOAD_ATTR_MODULE] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_LOAD_ATTR_WITH_HINT] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
-    [_LOAD_ATTR_SLOT] = HAS_DEOPT_FLAG,
+    [_LOAD_ATTR_SLOT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_CHECK_ATTR_CLASS] = HAS_EXIT_FLAG,
-    [_LOAD_ATTR_CLASS] = 0,
+    [_LOAD_ATTR_CLASS] = HAS_ESCAPES_FLAG,
     [_LOAD_ATTR_PROPERTY_FRAME] = HAS_ARG_FLAG | HAS_DEOPT_FLAG,
     [_GUARD_DORV_NO_DICT] = HAS_EXIT_FLAG,
     [_STORE_ATTR_INSTANCE_VALUE] = HAS_ESCAPES_FLAG,
@@ -185,7 +185,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_COMPARE_OP_FLOAT] = HAS_ARG_FLAG,
     [_COMPARE_OP_INT] = HAS_ARG_FLAG | HAS_DEOPT_FLAG,
     [_COMPARE_OP_STR] = HAS_ARG_FLAG,
-    [_IS_OP] = HAS_ARG_FLAG,
+    [_IS_OP] = HAS_ARG_FLAG | HAS_ESCAPES_FLAG,
     [_CONTAINS_OP] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_GUARD_TOS_ANY_SET] = HAS_DEOPT_FLAG,
     [_CONTAINS_OP_SET] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
@@ -194,7 +194,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_CHECK_EXC_MATCH] = HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_ESCAPES_FLAG,
     [_IMPORT_NAME] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_IMPORT_FROM] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
-    [_IS_NONE] = 0,
+    [_IS_NONE] = HAS_ESCAPES_FLAG,
     [_GET_LEN] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_MATCH_CLASS] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_MATCH_MAPPING] = 0,
@@ -278,7 +278,7 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_MAKE_FUNCTION] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_SET_FUNCTION_ATTRIBUTE] = HAS_ARG_FLAG,
     [_RETURN_GENERATOR] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
-    [_BUILD_SLICE] = HAS_ARG_FLAG | HAS_ERROR_FLAG,
+    [_BUILD_SLICE] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_CONVERT_VALUE] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_FORMAT_SIMPLE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_FORMAT_WITH_SPEC] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
diff --git a/Tools/cases_generator/analyzer.py b/Tools/cases_generator/analyzer.py
index 2b3a90c7db9b44..63881f8aa9cb32 100644
--- a/Tools/cases_generator/analyzer.py
+++ b/Tools/cases_generator/analyzer.py
@@ -832,7 +832,7 @@ def compute_properties(op: parser.CodeDef) -> Properties:
         )
     error_with_pop = has_error_with_pop(op)
     error_without_pop = has_error_without_pop(op)
-    escapes = bool(escaping_calls)
+    escapes = bool(escaping_calls) or variable_used(op, "DECREF_INPUTS")
     pure = False if isinstance(op, parser.LabelDef) else "pure" in op.annotations
     no_save_ip = False if isinstance(op, parser.LabelDef) else "no_save_ip" in op.annotations
     return Properties(