Ensure Python (>= 2.7) is installed for compiling the sources. You will need Python 3 to run the Python programs itself.

Install Pandoc >= 1.11.1 from http://johnmacfarlane.net/pandoc/installing.html

Install pdflatex from http://www.tug.org/texlive/. Note that Mac users can install MacTex.pkg from http://www.tug.org/mactex/2012/.

Install pip if not present already:

sudo sh -c "curl -k -O https://raw.github.com/pypa/pip/master/contrib/get-pip.py && python get-pip.py && rm get-pip.py"

Install Python libraries needed:

sudo pip install -r requirements.txt

Convert the source files into HTML files:

fab html

Convert the source files into PDF:

fab pdf

Convert the source files into EPUB (ebook):

fab epub

If you're using Emacs, you must use Jason Blevins' Markdown Mode.

If you're using Vim, then you may like the vim-pandoc plugin. There is one downside though - for long chapters, it becomes really slow, so I edit only in plain text mode (:set ft=), but when reviewing, I use the pandoc (:set ft=pandoc) mode.