pandas-dev
diff --git a/‎doc/source/whatsnew/v1.2.4.rst
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diff --git a/‎pandas/_libs/tslibs/nattype.pyx
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diff --git a/‎pandas/tests/scalar/test_nat.py
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@@ -17,6 +17,7 @@ Fixed regressions
 
 - Fixed regression in :meth:`DataFrame.sum` when ``min_count`` greater than the :class:`DataFrame` shape was passed resulted in a ``ValueError`` (:issue:`39738`)
 - Fixed regression in :meth:`DataFrame.to_json` raising ``AttributeError`` when run on PyPy (:issue:`39837`)
+- Fixed regression in (in)equality comparison of ``pd.NaT`` with a non-datetimelike numpy array returning a scalar instead of an array (:issue:`40722`)
 - Fixed regression in :meth:`DataFrame.where` not returning a copy in the case of an all True condition (:issue:`39595`)
 - Fixed regression in :meth:`DataFrame.replace` raising ``IndexError`` when ``regex`` was a multi-key dictionary (:issue:`39338`)
 -
 
@@ -124,6 +124,10 @@ cdef class _NaT(datetime):
                 result.fill(_nat_scalar_rules[op])
             elif other.dtype.kind == "O":
                 result = np.array([PyObject_RichCompare(self, x, op) for x in other])
+            elif op == Py_EQ:
+                result = np.zeros(other.shape, dtype=bool)
+            elif op == Py_NE:
+                result = np.ones(other.shape, dtype=bool)
             else:
                 return NotImplemented
             return result
 
@@ -575,6 +575,47 @@ def test_nat_comparisons_invalid(other, op):
         op(other, NaT)
 
 
+@pytest.mark.parametrize(
+    "other",
+    [
+        np.array(["foo"] * 2, dtype=object),
+        np.array([2, 3], dtype="int64"),
+        np.array([2.0, 3.5], dtype="float64"),
+    ],
+    ids=["str", "int", "float"],
+)
+def test_nat_comparisons_invalid_ndarray(other):
+    # GH#40722
+    expected = np.array([False, False])
+    result = NaT == other
+    tm.assert_numpy_array_equal(result, expected)
+    result = other == NaT
+    tm.assert_numpy_array_equal(result, expected)
+
+    expected = np.array([True, True])
+    result = NaT != other
+    tm.assert_numpy_array_equal(result, expected)
+    result = other != NaT
+    tm.assert_numpy_array_equal(result, expected)
+
+    for symbol, op in [
+        ("<=", operator.le),
+        ("<", operator.lt),
+        (">=", operator.ge),
+        (">", operator.gt),
+    ]:
+        msg = f"'{symbol}' not supported between"
+
+        with pytest.raises(TypeError, match=msg):
+            op(NaT, other)
+
+        if other.dtype == np.dtype("object"):
+            # uses the reverse operator, so symbol changes
+            msg = None
+        with pytest.raises(TypeError, match=msg):
+            op(other, NaT)
+
+
 def test_compare_date():
     # GH#39151 comparing NaT with date object is deprecated
     # See also: tests.scalar.timestamps.test_comparisons::test_compare_date
Original file line number	Diff line number	Diff line change
`@@ -17,6 +17,7 @@ Fixed regressions`
`17`	`17`
`18`	`18`	- Fixed regression in :meth:`DataFrame.sum` when ``min_count`` greater than the :class:`DataFrame` shape was passed resulted in a ``ValueError`` (:issue:`39738`)
`19`	`19`	- Fixed regression in :meth:`DataFrame.to_json` raising ``AttributeError`` when run on PyPy (:issue:`39837`)
	`20`	+- Fixed regression in (in)equality comparison of ``pd.NaT`` with a non-datetimelike numpy array returning a scalar instead of an array (:issue:`40722`)
`20`	`21`	- Fixed regression in :meth:`DataFrame.where` not returning a copy in the case of an all True condition (:issue:`39595`)
`21`	`22`	- Fixed regression in :meth:`DataFrame.replace` raising ``IndexError`` when ``regex`` was a multi-key dictionary (:issue:`39338`)
`22`	`23`	`-`