diff --git a/setup.py b/setup.py
index c33b37d..fed66ab 100644
--- a/setup.py
+++ b/setup.py
@@ -47,8 +47,8 @@
         # Until this issue is closed
         # https://github.com/googleapis/google-cloud-python/issues/10566
         "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-        "proto-plus >= 1.15.0, <2.0.0dev",
-        "protobuf >= 3.19.0, <4.0.0dev",
+        "proto-plus >= 1.22.0, <2.0.0dev",
+        "protobuf >= 3.19.0, <5.0.0dev",
         "grpc-google-iam-v1 >=0.12.4, <1.0.0dev",
     ),
     python_requires=">=3.7",
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index 60b7a7a..21ecd85 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -6,6 +6,6 @@
 # e.g., if setup.py has "foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have foo==1.14.0
 google-api-core==1.31.5
-proto-plus==1.15.0
+proto-plus==1.22.0
 grpc-google-iam-v1==0.12.4
 protobuf==3.19.0