diff --git a/samples/create_assay_domain_example.py b/samples/create_assay_domain_example.py
new file mode 100644
index 0000000..a3e117c
--- /dev/null
+++ b/samples/create_assay_domain_example.py
@@ -0,0 +1,74 @@
+#
+# Copyright (c) 2024 LabKey Corporation
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+#
+from labkey.api_wrapper import APIWrapper
+
+labkey_server = "localhost:8080"
+container_path = "Tutorials/HIV Study"  # Full project/folder container path
+api = APIWrapper(labkey_server, container_path, use_ssl=False)
+
+###################
+# Create an assay protocol
+###################
+
+# Define run domain fields
+run_fields = [
+    {"name": "runRunRun"}
+]
+
+# Define result domain fields
+result_fields = [
+    {"name": "resultResultResult"},
+    {
+        "conceptURI": "http://www.labkey.org/exp/xml#sample",
+        "lookupQuery": "Materials",
+        "lookupSchema": "exp",
+        "name": "sampleLookupField",
+        "rangeURI": "http://www.w3.org/2001/XMLSchema#int"
+    }
+]
+
+# Specify the assay protocol definition
+assay_protocol_definition = {
+    "editableResults": True,
+    "editableRuns": True,
+    "domains": [
+        {
+            "domainKindName": "Assay",
+            "domainURI": "urn:lsid:${LSIDAuthority}:AssayDomain-Batch.Folder-${Container.RowId}:${GpatAssayDBSeq}",
+            "name": "Batch Fields"
+        },
+        {
+            "domainKindName": "Assay",
+            "domainURI": "urn:lsid:${LSIDAuthority}:AssayDomain-Run.Folder-${Container.RowId}:${GpatAssayDBSeq}",
+            "name": "Run Fields",
+            "fields": run_fields
+        },
+        {
+            "domainKindName": "Assay",
+            "domainURI": "urn:lsid:${LSIDAuthority}:AssayDomain-Data.Folder-${Container.RowId}:${GpatAssayDBSeq}",
+            "name": "Data Fields",
+            "fields": result_fields
+        }
+    ],
+    "name": "Assay Protocol Created Using Python",
+    "providerName": "General"
+}
+
+url = api.server_context.build_url("assay", "saveProtocol.api", container_path=container_path)
+assay_protocol = api.server_context.make_request(url, json=assay_protocol_definition)
+
+# Display a success message
+print(assay_protocol["message"])