Repligen
 | Parts of this article (those related to Entire article) need to be updated. The reason given is: hasn't been materially touched since 2014. (August 2022) |
 | |
| Company type | Public |
|---|---|
| Nasdaq: RGEN S&P 400 Component | |
| Industry | Biotechnology Laboratory equipment |
| Founded | 1981 |
| Founders | Alexander Rich Paul Schimmel |
| Headquarters | Waltham, Massachusetts , United States |
Key people | Olivier Loeillot (president and CEO [as of 2024])[1] |
| Products | Materials used in the manufacture of biological drugs |
| Revenue |  US$634 million (2024) |
Number of employees | Over 1,900 globally |
| Website | repligen |
Repligen Corporation is a global life sciences company devoted to the development and commercialization of innovative bioprocessing technologies and systems that enable efficiencies in the process of manufacturing biological drugs.2025 The company is based in Waltham, Massachusetts,2014 and was incorporated in Delaware in 1981.[2] A public company, Repligen is listed on the NASDAQ exchange under the symbol RGEN.[3] As of 2025, Repligen employs over 1,900 employees globally and serves primarily biopharmaceutical drug developers and contract development and manufacturing organizations (CDMOs) worldwide.
Business model
[edit]Before 2012, Repligen maintained dual capabilities in developing pharmaceutical therapeutics (drug discovery and development) and the development of materials supporting biological drug manufacture (bioprocessing business).[4] A decision was made in 2012 to focus on the bioprocessing business and reduce research and development expenditures.[5] As of 2024, Repligen's product portfolio includes filtration and fluid management, Chromatography, process analytics and proteins, serving a wide range of biologics including monoclonal antibodies (mAbs), Antibody–drug conjugates (ADCs), bispecific antibodies, fusion proteins, mRNA, and cell and gene therapies.
Sales
[edit]Repligen employs a direct sales model to users of its products in the United States, with some sales through intermediaries in "certain foreign markets".[6] Repligen now serves a global customer base with significant growth in North America, Europe, and Asia-Pacific.
Facilities
[edit]Repligen's company headquarters are housed together with its manufacturing facility in Waltham, Massachusetts.[7]
Headquartered at Waltham, Massachusetts, Repligen operates across 22 sites globally in the United States, Europe, and Asia Pacific. Growth factor products and the native form of Protein A and recombinant Protein A are manufactured in Sweden; assembly of the OPUS chromatography product line is done in the United States.[8]
Corporate history and governance
[edit]Alexander Rich was a co-founder of Repligen and served as Chairman Emeritus[9] of Repligen's board of directors. Rich had been a member of the Board since 1981.[10] Paul Schimmel is also a co-founder of Repligen, and he is the Ernest and Jean Hahn Professor at The Skaggs Institute for Chemical Biology at The Scripps Research Institute. He used to be the John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics in the Department of Biology at MIT. Tony J. Hunt, who actively serves as executive chairman for the board, was the company's President and Chief Executive Officer from 2015 to 2024.
As of 2024[update], the company's President and Chief Executive Officer is Olivier Loeillot.
Acquisitions and in-licensing
[edit]In 2010, Repligen licensed technology from BioFlash which it subsequently incorporated into the OPUS line of pre-packed chromatography columns.[11]
In 2011, Repligen acquired bioproduction assets from Novozymes, which doubled the company's bioprocessing capabilities.[4]
In 2014, Repligen acquired Alternating Tangential Flow (ATF) system from Refine Technology.[12]
In December 2016, Repligen acquired TangenX.[13]
in June 2017, Spectrum Laboratories Inc. was acquired.[14]
In May 2019, C Technologies was acquired.[15]
In 2020, ARTeSYN Biosolutions wad acquired, expanding on the company's filtration an chromatography systems strategy.[16]
In June 2021, Polymem S.A. was acquired.[17]
In September 2021, Avitide, Inc. was acquired.[18]
In December 2021, BioFlex Solutions was acquired.[19]
In April 2023, Flexbiosys Inc. was acquired.[20]
In September 2023, Repligen acquired magnetic mixer manufacturer, Metenova.[21]
At the end of 2024, Tantti Laboratory Inc. was acquired.[22]
In 2025, Repligen acquired four process analytics technologies assets from chemical analysis tech firm 908 Devices.[23]
Divestments and out-licensing
[edit]In 2008, an agreement was struck to divest certain intellectual property rights to Bristol-Myers Squibb around the drug Orencia in exchange for ongoing royalty payments through the end of 2013.[4]
At the end of 2012, Repligen out-licensed its spinal muscular atrophy program, in particular the small molecule candidate drug RG3039, to Pfizer.[4] This divestment included licensing rights to two patents to Pfizer.[8][24][25]
At the start of 2014, the company out-licensed its Friedreich's ataxia program, including a library of histone deacetylase inhibitor compounds, to BioMarin Pharmaceutical for US$2,000,000 and future milestone and royalty payments.[2][26]
Terminations and moth-balling
[edit]Development of an imaging agent, designated RG1068, based on a synthetic human hormone was halted in 2012 following a request by the USFDA for additional safety and efficacy data beyond that provided in a New Drug Application (NDA) submission; a Marketing Authorization Application had been submitted in parallel to the EMA.[2]
Products and services
[edit]Repligen was a major supplier of Protein A, both native and recombinant forms, to the pharmaceutical industry.[4] In 2010-2013, Protein A accounted for the majority of the company's product sales.[11] The company also provides growth factors to increase the productivity of cell-based bioproduction, multiple alternating tangential flow (ATF) systems, and a line (OPUS) of chromatography columns scaled to manufacture of product for testing in clinical trials.[4]
Today, the company's suite of offerings has been diversified by its many acquisitions and partnerships. In downstream bioprocessing, Repligen offers tangential flow filtration systems (Cross-flow filtration), flat sheet cassettes, hollow fiber filters, single-use components, assemblies, mixers, chromatography systems, pre-packed columns, and resins. Within upstream bioprocessing they offer alternating tangential flow filtration systems (ATF), tangential flow depth filtration systems (TFDF), tangential flow filtration systems and cell culture supplements. Across the entire bioproduction workflow there are Process analytical technology (PAT) devices offered as standalone solutions or directly integrated onto filtration systems.
Some Repligen products include, but are not limited to:
- AVIPure® AAV Affinity Resins
- CTech™ SoloVPE® PLUS System
- CTech™ FlowVPE® PLUS System
- Fluid Management
- KRM® Chromatography System
- KrosFlo® TFF Systems
- MAVEN® System
- MAVERICK® System
- Metenova®
- OPUS® Pre-Packed Columns
- ProConnex® Flow Paths
- ProConnex® MixOne RG-X
- REBEL® Smart® System
- TangenX® Cassettes
- XCell® ATF Systems
Launches and Innovations
[edit]In 2023, Repligen launched the KrosFlo® RS 10 TFF system, introducing the first laboratory scale tangential flow filtration system built specifically for Biomanufacturing with adherence to Current Good Manufacturing Practices (cGMP). During the same year, the company released a self-contained, holder less TFF device called the TangenX® SC.
In 2025, the company launched the CTech™ SoloVPE PLUS System, their UV-based Variable Pathlength Technology system.[27]
Notes
[edit]- ^ https://investors.repligen.com/press-releases/news-details/2024/Repligen-Announces-CEO-Transition-Plan/default.aspx
- ^ a b c Repligen 2013 10-K 2014, p. 2.
- ^ Nasdaq: RGEN
- ^ a b c d e f Repligen 2013 10-K 2014, p. 1.
- ^ Repligen 2013 10-K 2014, p. 4.
- ^ Repligen 2013 10-K 2014, p. 5.
- ^ Repligen 2013 10-K 2014, p. 19.
- ^ a b Repligen 2013 10-K 2014, p. 7.
- ^ Motley Fool 2014.
- ^ Forbes 2014.
- ^ a b Repligen 2013 10-K 2014, p. 3.
- ^ "Repligen Acquires Bioprocessing Business of Refine Technology". BioProcess International. Retrieved 2025-10-10.
- ^ "Repligen Acquires TangenX for $39M". 15 December 2016.
- ^ "Repligen Merging with Spectrum Labs in $359M Deal". GEN. June 23, 2017. Retrieved August 15, 2025.
- ^ Corporation, Repligen (2019-04-26). "Repligen Corporation Announces Agreement to Acquire Process Analytics Innovator C Technologies and Reports Preliminary First Quarter 2019 Financial Results". GlobeNewswire News Room. Retrieved 2025-10-10.
- ^ Corporation, Repligen (2020-10-27). "Repligen Corporation Announces Agreement to Acquire Bioprocess Systems Innovator ARTeSYN Biosolutions and Completes Acquisition of Non-Metallic Solutions". GlobeNewswire News Room. Retrieved 2025-10-10.
- ^ "Repligen Corporation Announces Agreement to Acquire Polymem S.A." investors.repligen.com. Retrieved 2025-10-10.
- ^ "Repligen Announces Agreement to Acquire Avitide, Inc. | Avitide". Retrieved 2025-10-10.
- ^ "Repligen | Inspiring advances in bioprocessing". Repligen. Retrieved 2025-10-10.
- ^ "Repligen Acquires FlexBiosys". Repligen. Retrieved 2025-10-10.
- ^ "Repligen (RGEN) to Acquire Fluid Management Company Metenova". Nasdaq.com. September 27, 2023.
- ^ "Repligen Announces Agreement to Acquire Chromatography Innovator Tantti". www.tantti.com. 2024-07-29. Retrieved 2025-10-10.
- ^ "Repligen lays down $70m to buy PAT tools from 908 Devices". BioProcess International. Retrieved 2025-10-10.
- ^ US 7888366 "2,4-diaminoquinazolines for spinal muscular atrophy"
- ^ US 7985755 "2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY"
- ^ Gen. Eng. Biotechnol. News 2014.
- ^ "Repligen Launches the CTech™ SoloVPE® PLUS System". investors.repligen.com. Retrieved 2025-10-10.
References
[edit]- Forbes (2014). "Alexander Rich". Profiles. Forbes. Archived from the original on 15 March 2014. Retrieved 15 March 2014.
- Gen. Eng. Biotechnol. News (February 15, 2014). "BioMarin Nabs Repligen's HDACi Compound Library". News: Discovery & Development. Gen. Eng. Biotechnol. News (paper). Vol. 34, no. 4. p. 14.
- International New York Times (2014). "Repligen Corporation". Business Day. International New York Times. Company Information. Archived from the original on 15 March 2014. Retrieved 15 March 2014.
- Motley Fool (2014). "Repligen Corp Key Executives RGEN". The Motley Fool. Archived from the original on 15 March 2014. Retrieved 15 March 2014.
- "Repligen Corporation, Form 10-K, 2013", SEC Documents, Form 10-K, Repligen, 2014, Commission File Number 000-14656, retrieved 16 March 2014
- Street Insider (19 September 2011). "Repligen (RGEN) Replaces Board Member Alex Rich with Alfred Goldberg". Street Insider. Archived from the original on 15 March 2014. Retrieved 15 March 2014.
External links
[edit]- Business data for Repligen Corporation:
