2-ethylmalate synthase
| 2-ethylmalate synthase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC no. | 2.3.3.6 | ||||||
| CAS no. | 9024-01-5 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / QuickGO | ||||||
|
2-ethylmalate synthase (EC 2.3.3.6) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme characterised from Saccharomyces cerevisiae are α-ketobutyric acid, acetyl-CoA, and water. Its products are (R)-2-ethylmalic acid and coenzyme A.[1]
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming). Other names in common use include (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating), 2-ethylmalate-3-hydroxybutanedioate synthase, propylmalate synthase, and propylmalic synthase.[2]
References
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