2-Hydroxysaclofen

2-Hydroxysaclofen
Names
	Preferred IUPAC name 3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
Identifiers
CAS Number	117354-64-0;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:111179;
ChEMBL	ChEMBL1256573;
ChemSpider	1509;
EC Number	634-206-2;
IUPHAR/BPS	1068;
PubChem CID	1564;
UNII	X5IFR0UF10;
CompTox Dashboard (EPA)	DTXSID30922408 ;
	InChI Key: WBSMZVIMANOCNX-UHFFFAOYSA-N; InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15);
	SMILES C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl;
Properties
Chemical formula	C9H12ClNO4S
Molar mass	265.71 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

2-Hydroxysaclofen is a GABA_B receptor antagonist and an analogue of saclofen.

Pharmacodynamics

2-Hydroxysaclofen binds to the GABA_B receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABA_B protein.^[1]

2-Hydroxysaclofen has been reported to be more potent than saclofen.^[2]

References

↑ Froestl, Wolfgang; Enna, S.J. (2007). "2-Hydroxysaclofen". XPharm: The Comprehensive Pharmacology Reference. pp. 1–6. doi:10.1016/B978-008055232-3.61101-8. ISBN 978-0-08-055232-3.
↑ "2-Hydroxysaclofen".

[1] Froestl, Wolfgang; Enna, S.J. (2007). "2-Hydroxysaclofen". XPharm: The Comprehensive Pharmacology Reference. pp. 1–6. doi:10.1016/B978-008055232-3.61101-8. ISBN 978-0-08-055232-3.

[2] "2-Hydroxysaclofen".

[1]

[2]

Pharmacodynamics

See also

References