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First published May 1969
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THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

A. G. E. PEARSEView all authors and affiliations
Volume 17, Issue 5
https://doi.org/10.1177/17.5.303

Abstract

A group of apparently unrelated endocrine cells, some in endocrine glands, others in nonendocrine tissues, share a number of cytochemical and ultrastructural characteristics. These characteristics, from the initial letters of four of which the term APUD is derived, indicate the possession of a common metabolic pattern and common synthetic, storage and secretion mechanisms. It is postulated that the various characteristics reflect the production and storage of hormone precursor protein which has a predominantly random coil conformation. Several explanations are possible to account for the APUD characteristics but if the cells, in fact, share a common ancestor the only possible candidate is the neural crest cell.

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Volume 17, Issue 5
Pages: 303 - 313
Article first published: May 1969
Issue published: May 1969

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1969, THE HISTOCHEMICAL SOCIETY, INC.
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PubMed: 4143745

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A. G. E. PEARSE
Royal postgraduate Medical School, London, England
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This article was published in Journal of Histochemistry & Cytochemistry.

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